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Discovery and optimization of 3-thiophenylcoumarins as novel agents against Parkinson's disease: Synthesis, in vitro and in vivo studies
3-Thiophenylcoumarins...
DPPH scavengers
monoamine oxidase B i...
Neuroprotectors
Open field test
Parkinson's disease
3 (4' bromothiophen 2...
3 (4' bromothiophen 2...
3 (4' bromothiophen 2...
3 thiophenylcoumarin ...
7 hydroxy 3 (thiophen...
7,8 dihydroxy 3 (thio...
8 hydroxy 3 (thiophen...
amine oxidase (flavin...
amine oxidase (flavin...
coumarin derivative
hydrogen peroxide
levodopa
selegiline
unclassified drug
animal cell
animal experiment
animal model
antioxidant activity
Article
controlled study
DPPH radical scavengi...
drug potency
drug selectivity
drug synthesis
embryo
enzyme inhibition
female
IC50
in vitro study
in vivo study
locomotion
male
motor cortex
mouse
neuroprotection
neurotoxicity
nonhuman
open field test
Parkinson disease
priority journal
rat
structure activity re...