The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish
Autor
Aragona, Marialuisa
Porcino, Caterina
Guerrera, Maria Cristina
Montalbano, Giuseppe
Laurà, Rosaria
Cometa, Marzio
Levanti, Maria Beatrice
Abbate, Francesco
Cobo, Teresa
Capitelli, Gabriel
Vega, Jose Antonio
Germanà, Antonino M.
Resumen
The brain-derived neurotrophic factor (BDNF) was discovered in the last century, and identified as a member of the neurotrophin family. BDNF shares approximately 50% of its amino acid with other neurotrophins such as NGF, NT-3 and NT-4/5, and its linear amino acid sequences in zebrafish (Danio rerio) and human are 91% identical. BDNF functions can be mediated by two categories of receptors: p75NTR and Trk. Intriguingly, BDNF receptors were highly conserved in the process of evolution, as were the other NTs’ receptors. In this review, we update current knowledge about the distribution and functions of the BDNF-TrkB system in the sensory organs of zebrafish. In fish, particularly in zebrafish, the distribution and functions of BDNF and TrkB in the brain have been widely studied. Both components of the system, associated or segregated, are also present outside the central nervous system, especially in sensory organs including the inner ear, lateral line system, retina, taste buds and olfactory epithelium.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Localization of BDNF and Calretinin in Olfactory Epithelium and Taste Buds of Zebrafish (Danio rerio) (2024)
Aragona, Marialuisa; Porcino, Caterina; Guerrera, Maria Cristina; Montalbano, Giuseppe; Laurà, Rosaria; Levanti, Maria; Abbate, Francesco; Cobo, Teresa; Capitelli, Gabriel; Calapai, Fabrizio; ... (MDPI, 2022)Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and it is involved in several fundamental functions in the central and peripheral nervous systems, and in sensory organs. BDNF regulates the ... -
Article
Potential Neuroprotective Role of Calretinin-N18 and Calbindin-D28k in the Retina of Adult Zebrafish Exposed to Different Wavelength Lights (2024)
Porcino, Caterina; Briglia, Marilena; Aragona, Marialuisa; Mhalhel, Kamel; Laurà, Rosaria; Levanti, Maria; Abbate, Francesco; Montalbano, Giuseppe; Germanà, Germana; Lauriano, Eugenia Rita; ... (MDPI, 2023)The incidence rates of light-induced retinopathies have increased significantly in the last decades because of continuous exposure to light from different electronic devices. Recent studies showed that exposure to blue ... -
Article
Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish (2020)
Montalbano G.; Mania M.; Abbate F.; Navarra M.; Guerrera M.C.; Laura R.; Vega J.A.; Levanti M.; Germanà A. (Humana Press Inc., 2018)