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SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
dc.contributor.author | Jing, Yukai | |
dc.contributor.author | Luo, Li | |
dc.contributor.author | Chen, Ying | |
dc.contributor.author | Westerberg, Lisa S. | |
dc.contributor.author | Zhou, Peng | |
dc.contributor.author | Xu, Zhiping | |
dc.contributor.author | Herrada, Andrés Alonso | |
dc.contributor.author | Park, Chan-sik | |
dc.contributor.author | Kubo, Masato | |
dc.contributor.author | Mei, Heng | |
dc.contributor.author | Hu, Yu | |
dc.contributor.author | Lee, Pamela Pui Wah | |
dc.date.accessioned | 2021-10-05T14:43:38Z | |
dc.date.available | 2021-10-05T14:43:38Z | |
dc.date.issued | 2021-12 | |
dc.identifier | 10.1038/s41392-021-00749-3 | |
dc.identifier.issn | 20959907 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/9613 | |
dc.description.abstract | The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.title | SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism | es_ES |
dc.type | Article | es_ES |