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Effect of a ketogenic diet on the nutritional parameters of obese patients: A systematic review and meta-analysis
dc.contributor.author | López Espinoza, Miguel Ángel | |
dc.contributor.author | Chacón-Moscoso, Salvador | |
dc.contributor.author | Sanduvete-Chaves, Susana | |
dc.contributor.author | Ortega-Maureira, María José | |
dc.contributor.author | Barrientos-Bravo, Tamara | |
dc.date.accessioned | 2021-09-10T01:59:38Z | |
dc.date.available | 2021-09-10T01:59:38Z | |
dc.date.issued | 2021-09 | |
dc.identifier | 10.3390/nu13092946 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/9508 | |
dc.description.abstract | The effect of a ketogenic diet (KD) on biochemical parameters and nutritional status has been the subject of debate over the years, as several randomized clinical trials (RCTs) obtained different results. Method: A systematic review and random-effects meta-analysis of RCTs comparing KD with a balanced diet was performed by means of a search of PubMed, Cochrane Library, Scopus, and Web of Science. Trials where the method for measuring the response variables was unclear, those that considered pathologies other than chronic non-communicable diseases and those with participants receiving pharmacological treatment for obesity were excluded from the comparison. Results: Of the studies included in the meta-analysis, no statistically significant standardized mean differences were observed for body mass index (BMI) (d = −0.457, p = 0.359), total cholesterol, COL-T (d = 0.230, p = 0.591), high-density lipoprotein, HDL (d = −0.028, p = 0.934), low-density lipoprotein, LDL (d = 0.528, p = 0.173), or triglycerides, TG (d = −0.283, p = 0.222), with high values of heterogeneity. The percentage of women included in the studies is a significant moderating variable in terms of BMI ratio (z = −6.68, p < 0.001) and TG (z = −2.27, p = 0.023). Conclusion: A KD shows no more benefits on nutritional parameters than a balanced diet, and adverse effects of being on the diet are sometimes reported. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.subject | KD | es_ES |
dc.subject | Ketogenic diet | es_ES |
dc.subject | Meta-analysis | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Systematic review | es_ES |
dc.title | Effect of a ketogenic diet on the nutritional parameters of obese patients: A systematic review and meta-analysis | es_ES |
dc.type | Article | es_ES |