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Carbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome
dc.contributor.author | Andrade, David Cristóbal | |
dc.contributor.author | Toledo, Camilo | |
dc.contributor.author | Díaz, Hugo S. | |
dc.contributor.author | Pereyra, Katherin V. | |
dc.contributor.author | Schwarz, Karla G. | |
dc.contributor.author | Díaz-Jara, Esteban | |
dc.contributor.author | Melipillán, Claudia A. | |
dc.contributor.author | Ríos-Gallardo, Angélica P. | |
dc.contributor.author | Uribe-Ojeda, Atenea | |
dc.contributor.author | Alcayaga, Julio | |
dc.contributor.author | Quintanilla, Rodrigo A. | |
dc.contributor.author | Iturriaga, R. | |
dc.date.accessioned | 2021-06-08T03:37:12Z | |
dc.date.available | 2021-06-08T03:37:12Z | |
dc.date.issued | 2021-06-01 | |
dc.identifier | 10.1097/HJH.0000000000002756 | |
dc.identifier.issn | 14735598 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8906 | |
dc.description.abstract | BACKGROUND AND OBJECTIVE: Chronic intermittent hypoxia (CIH), one of the main features of obstructive sleep apnea (OSA), enhances carotid body-mediated chemoreflex and induces hypertension and breathing disorders. The carbamylated form of erythropoietin (cEpo) may have beneficial effects as it retains its antioxidant/anti-inflammatory and neuroprotective profile without increasing red blood cells number. However, no studies have evaluated the potential therapeutic effect of cEpo on CIH-related cardiorespiratory disorders. We aimed to determine whether cEpo normalized the CIH-enhanced carotid body ventilatory chemoreflex, the hypertension and ventilatory disorders in rats. METHODS: Male Sprague-Dawley rats (250 g) were exposed to CIH (5% O2, 12/h, 8 h/day) for 28 days. cEPO (20 μg/kg, i.p) was administrated from day 21 every other day for one more week. Cardiovascular and respiratory function were assessed in freely moving animals. RESULTS: Twenty-one days of CIH increased carotid body-mediated chemoreflex responses as evidenced by a significant increase in the hypoxic ventilatory response (FiO2 10%) and triggered irregular eupneic breathing, active expiration, and produced hypertension. cEpo treatment significantly reduced the carotid body--chemoreflex responses, normalizes breathing patterns and the hypertension in CIH. In addition, cEpo treatment effectively normalized carotid body chemosensory responses evoked by acute hypoxic stimulation in CIH rats. CONCLUSION: Present results strongly support beneficial cardiorespiratory therapeutic effects of cEpo during CIH exposure. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | NLM (Medline) | es_ES |
dc.title | Carbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome | es_ES |
dc.type | Article | es_ES |