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Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer
dc.contributor.author | Astudillo, Pablo | |
dc.date.accessioned | 2021-03-10T13:49:36Z | |
dc.date.available | 2021-03-10T13:49:36Z | |
dc.date.issued | 2021-02-17 | |
dc.identifier | 10.7717/peerj.10869 | |
dc.identifier.issn | 21678359 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8663 | |
dc.description.abstract | To date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is usually regarded as a prototypical non-canonical Wnt ligand, and its expression has been related to cancer progression. On the other hand, YAP/TAZ transcriptional coactivators act in concert with TEAD transcription factors to control gene expression. Although one article has shown previously that WNT5A is a YAP/TEAD target gene, there is a need for further evidence supporting this regulatory relationship, because a possible YAP/Wnt5a regulatory circuit might have profound implications for cancer biology. This article analyzes publicly available ChIP-Seq, gene expression, and protein expression data to explore this relationship, and shows that WNT5A might be a YAP/TEAD target gene in several contexts. Moreover, Wnt5a and YAP expression are significantly correlated in specific cancer types, suggesting that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate than previously thought. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | PeerJ Inc. | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Signaling pathways | es_ES |
dc.subject | Transcription factors | es_ES |
dc.subject | Wnt5a | es_ES |
dc.subject | YAP | es_ES |
dc.title | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer | es_ES |
dc.type | Article | es_ES |