Trending Topics on Coumarin and Its Derivatives in 2020
Autor
Carneiro, Aitor
Matos, Maria João
Uriarte, Eugenio
Santana, Lourdes
Resumen
Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many research articles and reviews compile information on this important family of compounds. In this overview, the most recent research papers and reviews from 2020 are organized and analyzed, and a discussion on these data is included. Multiple electronic databases were scanned, including SciFinder, Mendeley, and PubMed, the latter being the main source of information. Particular attention was paid to the potential of coumarins as an important scaffold in drug design, as well as fluorescent probes for decaging of prodrugs, metal detection, and diagnostic purposes. Herein we do an analysis of the trending topics related to coumarin and its derivatives in the broad field of drug discovery.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Thiocoumarins: From the Synthesis to the Biological Applications (2024)
Matos, Maria J.; Santana, Lourdes; Uriarte, Eugenio; Borges, Fernanda (MDPI, 2022)Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins ... -
Article
Coumarin derivatives as promising xanthine oxidase inhibitors (2020)
Fais A.; Era B.; Asthana S.; Sogos V.; Medda R.; Santana L.; Uriarte E.; Matos M.J.; Delogu F.; Kumar A. (Elsevier B.V., 2018) -
Article
3-phenylcoumarins as a privileged scaffold in medicinal chemistry: The landmarks of the past decade (2021)
Matos, Maria J.; Uriarte, Eugenio; Santana, Lourdes (MDPI, 2021-11-01)3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects ...