The juxta-oral organ of Chievitz (organum yuxtaorale) updated: Embryology, anatomy, function and pathology
Autor
Suárez-Quintanilla, Juan Antonio
Martín-Cruces, José
Martin-Biedma, Benjamin
Cobo, Juan Luis
Mérida-García, A. J.
de Vicente, J. C.
Junquera, Luis
Mérida-Velasco, José Ramón
Vega, Jose Antonio
Resumen
Background: The Chievitz's organ or juxta-oral organ is a mysterious bilateral structure, phylogenetically preserved, which develops from the mouth epithelium as an invagination that loses connection to it in the prenatal period. It is located laterally to the walls of the oral cavity in an imprecise anatomical location and receives abundant innervation from the buccal nerve. Structurally it consists of non-keratinizing squamous-like neuroepithelial cells surrounded by two layers of connective tissue with nerve fibers and different morphotypes of sensory corpuscles. Its function is completely unknown although based on its rich innervation it is assumed that works as a mechanoreceptor. Methods: We have performed immunohistochemistry for axonal and Schwann cells, and the putative mechanoproteins ASIC2, TRPV4 and Piezo2 in sections of fetal juxta-oral organ. Results: Intraparenchymatous nerve fibers and sensory corpuscles were observed as well as immunoreactivity for Piezo2 in both nerve fibers and epithelial parenchymatous cells. Conclusions: We add indirect evidence that the juxtaoral organ is a mechanoreceptor because in addition to its dense innervation, the epithelial cells and sensory nerve fibers display immunoreactivity for the mechanogated ion channel Piezo2. Based on current knowledge, the functional and clinical importance of the juxta-oral organ should be further investigated.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament (2024)
Gaite, Juan J.; Solé-Magdalena, Antonio; García-Mesa, Yolanda; Cuendias, Patricia; Martin-Cruces, José; García-Suárez, Olivia; Cobo, Teresa; Vega, José A.; Martín-Biedma, Benjamín (John Wiley and Sons Inc, 2023)PIEZO1 and PIEZO2 are essential components of mechanogated ion channels, which are required for mechanotransduction and biological processes associated with mechanical stimuli. There is evidence for the presence of PIEZO1 ... -
Article
Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity (2024)
García-Mesa, Yolanda; Martín-Sanz, Raquel; García-Piqueras, Jorge; Cobo, Ramón; Muñoz-Bravo, Saray; García-Suárez, Olivia; Martín-Biedma, Benjamín; Vega, José Antonio; Feito, Jorge (MDPI, 2022)As an essential component of mechano-gated ion channels, critically required for mecha-notransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we ... -
Article
Exploring somatosensory innervation of the human lip: A focus on the vermilion (2024)
Martín-Cruces, José; Martín-Biedma, Benjamín; García-Mesa, Yolanda; Cuendias, Patricia; Gaite, Juan J.; García-Suárez, Olivia; Cobo, Juan L.; Vega, José A. (Elsevier GmbH, 2023)Background: The lips are a vital component of the face and are densely innervated to perform various functions. The lip edges are covered with mucocutaneous tissue called vermilion which is particularly receptive to touch ...