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The role of ubiquitinase in B cell development and function

dc.contributor.authorZhang T.
dc.contributor.authorSun J.
dc.contributor.authorCheng J.
dc.contributor.authorYin W.
dc.contributor.authorLi J.
dc.contributor.authorMiller H.
dc.contributor.authorHerrada A.A.
dc.contributor.authorGu H.
dc.contributor.authorSong H.
dc.contributor.authorChen Y.
dc.contributor.authorGong Q.
dc.contributor.authorLiu C.
dc.date.accessioned2020-09-02T22:31:08Z
dc.date.available2020-09-02T22:31:08Z
dc.date.issued2020
dc.identifier10.1002/JLB.1MR0720-185RR
dc.identifier.issn07415400
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6734
dc.descriptionUbiquitinases are a select group of enzymes that modify target proteins through ubiquitination, which plays a crucial role in the regulation of protein degradation, location, and function. B lymphocytes that originated from bone marrow hematopoietic stem cells (HSC), exert humoral immune functions by differentiating into plasma cells and producing antibodies. Previous studies have shown that ubiquitination is involved in the regulation of the cell cycle and signal transduction important for B lymphocyte development and function. In this review, how ubiquitinases regulate B cell development, activation, apoptosis, and proliferation is discussed, which could help in understanding the physiological processes and diseases related to B cells and also provides potential new targets for further studies. ©2020 Society for Leukocyte Biology
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.subjectB cell
dc.subjectNF-κB
dc.subjectubiquitination
dc.titleThe role of ubiquitinase in B cell development and function
dc.typeReview


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