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Hair in Parkinson's disease patients exhibits differences in Calcium, Iron and Zinc concentrations measured by flame atomic absorption spectrometry − FAAS

dc.contributor.authordos Santos A.B.
dc.contributor.authorKohlmeier K.A.
dc.contributor.authorRocha M.E.
dc.contributor.authorBarreto G.E.
dc.contributor.authorBarreto J.A.
dc.contributor.authorde Souza A.C.A.
dc.contributor.authorBezerra M.A.
dc.date.accessioned2020-09-02T22:31:05Z
dc.date.available2020-09-02T22:31:05Z
dc.date.issued2018
dc.identifier10.1016/j.jtemb.2018.02.003
dc.identifier.citation47, , 134-139
dc.identifier.issn0946672X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6715
dc.descriptionImbalances in metals have emerged as playing a role in the pathophysiology of Parkinson's Disease (PD). Monitoring of metal levels could serve as a biomarker of presence, or future development, of this disease. To this end, we evaluated the ability of flame atomic absorption spectrometry (FAAS) to assess the concentrations of Ca, Fe and Zn in hair of PD patients and to investigate if there was an association with age and disease duration. Hair samples were collected from 26 clinically-diagnosed PD patients, and 33 healthy individuals. Concentrations of Ca and Fe were lower in PD patients when compared to control, whereas, a higher concentration of Zn was detected in PD patients. Levels of Ca and Fe did not vary with age nor with the duration of PD. While Zn did not present variation with duration of the disease, there was a correlation with age as PD patients older than 65 years exhibited a higher concentration of Zn than controls. We conclude that FAAS is useful for detecting differences in Fe, Ca and Zn in hair samples of patients with PD. Hair samples required for this method are easy to collect, and the technique relies on a simple method of digestion of the organic matrix. The ease of use of FAAS should allow for more frequent monitoring of metallic levels in patients in a variety of small clinical situations, thereby offering the hope of allowing systematic tracking of metal levels as the disease progresses, or prior to the defining motor symptoms. © 2018 Elsevier GmbH
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectAnalytical methods
dc.subjectMetals unbalance
dc.subjectNeurochemistry
dc.subjectNeurodegenerative disease
dc.subjectNeurotoxicity
dc.subjectcalcium
dc.subjectiron
dc.subjectzinc
dc.subjectcalcium
dc.subjectiron
dc.subjectlevodopa
dc.subjectzinc
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectArticle
dc.subjectatomic absorption spectrometry
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectfemale
dc.subjectflame atomic absorption spectrometry
dc.subjecthair analysis
dc.subjecthuman
dc.subjectmale
dc.subjectParkinson disease
dc.subjectpriority journal
dc.subjectcase control study
dc.subjectchemistry
dc.subjecthair
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectParkinson disease
dc.subjectprocedures
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCalcium
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHair
dc.subjectHumans
dc.subjectIron
dc.subjectLevodopa
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectParkinson Disease
dc.subjectSpectrophotometry, Atomic
dc.subjectZinc
dc.titleHair in Parkinson's disease patients exhibits differences in Calcium, Iron and Zinc concentrations measured by flame atomic absorption spectrometry − FAAS
dc.typeArticle


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