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Circulating microRNAs as emerging cardiac biomarkers responsive to acute exercise

dc.contributor.authorde Gonzalo-Calvo D.
dc.contributor.authorDávalos A.
dc.contributor.authorFernández-Sanjurjo M.
dc.contributor.authorAmado-Rodríguez L.
dc.contributor.authorDíaz-Coto S.
dc.contributor.authorTomás-Zapico C.
dc.contributor.authorMontero A.
dc.contributor.authorGarcía-González Á.
dc.contributor.authorLlorente-Cortés V.
dc.contributor.authorHeras M.E.
dc.contributor.authorBoraita Pérez A.
dc.contributor.authorDíaz-Martínez Á.E.
dc.contributor.authorÚbeda N.
dc.contributor.authorIglesias-Gutiérrez E.
dc.date.accessioned2020-09-02T22:31:01Z
dc.date.available2020-09-02T22:31:01Z
dc.date.issued2018
dc.identifier10.1016/j.ijcard.2018.02.092
dc.identifier.citation264, , 130-136
dc.identifier.issn01675273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6680
dc.descriptionBackground: Circulating microRNAs (c-miRNAs) are mediators of intercellular communication with great potential as cardiac biomarkers. The analysis of c-miRNAs in response to physiological stress, such as exercise, would provide valuable information for clinical practice and a deeper understanding of the molecular response to physical activity. Here, we analysed for the first time the acute exercise response of c-miRNAs reported as biomarkers of cardiac disease in a well-characterized cohort of healthy active adults. Methods: Blood samples were collected immediately before and after (0 h, 24 h, 72 h) a 10-km race, a half-marathon (HM) and a marathon (M). Serum RNA from 10-km and M samples was extracted and a panel of 74 miRNAs analysed using RT-qPCR. c-miRNA response was compared with a panel of nine cardiac biomarkers. Functional enrichment analysis was performed. Pre- and post-M echocardiographic analyses were carried out. Results: Serum levels of all cardiac biomarkers were upregulated in a dose-dependent manner in response to exercise, even in the absence of symptoms or signs of cardiac injury. A deregulation in the profiles of 5 and 19 c-miRNAs was observed for 10-km and M, respectively. Each race induced a specific qualitative and quantitative alteration of c-miRNAs implicated in cardiac adaptions. Supporting their discriminative potential, a number of c-miRNAs previously associated with cardiac disease were undetectable or stable in response to exercise. Conversely, “pseudo-disease” signatures were also observed. Conclusions: c-miRNAs may be useful for the management of cardiac conditions in the context of acute aerobic exercise. Translational aspects of the work: Circulating microRNAs could offer incremental diagnostic value to established and emerging cardiac biomarkers, such as hs-cTnT or NT-proBNP, in those patients with cardiac dysfunction symptoms after an acute bout of endurance exercise. Furthermore, circulating miRNAs could also show “pseudo-disease” signatures in response to acute exercise. Clinical practitioners should be aware of the impact caused by exercise in the interpretation of miRNA data. © 2018 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectBiomarkers
dc.subjectCirculating microRNAs
dc.subjectExercise
dc.subjectHeart disease
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjectcopeptin
dc.subjectcreatine kinase
dc.subjectcreatine kinase MB
dc.subjectfatty acid binding protein 3
dc.subjectgalectin 3
dc.subjectlactate dehydrogenase
dc.subjectmicroRNA
dc.subjectmyoglobin
dc.subjecttroponin T
dc.subjectbiological marker
dc.subjectcirculating microRNA
dc.subjectmicroRNA
dc.subjectMIRN103A2 microRNA, human
dc.subjectMIRN375 microRNA, human
dc.subjectadult
dc.subjectaerobic exercise
dc.subjectArticle
dc.subjectdiagnostic value
dc.subjectechocardiography
dc.subjectheart disease
dc.subjecthuman
dc.subjectmarathon runner
dc.subjectnormal human
dc.subjectpriority journal
dc.subjectreverse transcription polymerase chain reaction
dc.subjectblood
dc.subjectcardiac muscle
dc.subjectclassification
dc.subjectendurance
dc.subjectexercise
dc.subjectfemale
dc.subjectheart disease
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectphysiological stress
dc.subjectphysiology
dc.subjecttime factor
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectCirculating MicroRNA
dc.subjectExercise
dc.subjectFemale
dc.subjectHealthy Volunteers
dc.subjectHeart Diseases
dc.subjectHumans
dc.subjectMale
dc.subjectMicroRNAs
dc.subjectMiddle Aged
dc.subjectMyocardium
dc.subjectPhysical Endurance
dc.subjectStress, Physiological
dc.subjectTime Factors
dc.titleCirculating microRNAs as emerging cardiac biomarkers responsive to acute exercise
dc.typeArticle


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