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Metabolic effects of antidiabetic drugs on adipocytes and adipokine expression

dc.contributor.authorYaribeygi H.
dc.contributor.authorSimental-Mendía L.E.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:30:36Z
dc.date.available2020-09-02T22:30:36Z
dc.date.issued2019
dc.identifier10.1002/jcp.28420
dc.identifier.citation234, 10, 16987-16997
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6644
dc.descriptionSeveral classes of antidiabetic agents have been developed that achieve their hypoglycemic outcomes via various molecular mechanisms. Adipose tissue is a major metabolic and energy-storing tissue and plays an important role in many metabolic pathways, including insulin signaling and insulin sensitivity. Adipose tissue monitors and regulates whole body homeostasis via production and release of potent proteins, such as adipokine and adiponectin, into the circulation. Therefore, any agent that can modulate adipocyte metabolism can, in turn, affect metabolic and glucose homeostatic pathways. Antidiabetic drugs are not only recognized primarily as hypoglycemic agents but may also alter adipose tissue itself, as well as adipocyte-derived adipokine expression and secretion. In the current review, we present the major evidence concerning routinely used antidiabetic agents on adipocyte metabolism and adipokine expression. © 2019 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectadipocyte
dc.subjectadipokine
dc.subjectadiponectin
dc.subjectantidiabetic agent
dc.subjectdiabetes mellitus
dc.subjectinflammation
dc.subjectthiazolidinedione
dc.subjectadipocytokine
dc.subjectantidiabetic agent
dc.subjectbiguanide derivative
dc.subjectdipeptidyl peptidase IV inhibitor
dc.subjectglucagon like peptide 1 receptor agonist
dc.subjectinsulin
dc.subjectsodium glucose cotransporter 2 inhibitor
dc.subjectsulfonylurea
dc.subjectadipocytokine
dc.subjectantidiabetic agent
dc.subjectadipocyte
dc.subjectadipose tissue
dc.subjectdiabetes mellitus
dc.subjectdiabetic complication
dc.subjectdisease classification
dc.subjectdrug classification
dc.subjectdrug effect
dc.subjecthuman
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectReview
dc.subjectadipocyte
dc.subjectanimal
dc.subjectbiosynthesis
dc.subjectdrug effect
dc.subjectAdipocytes
dc.subjectAdipokines
dc.subjectAnimals
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.titleMetabolic effects of antidiabetic drugs on adipocytes and adipokine expression
dc.typeReview


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