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Antioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients

dc.contributor.authorYaribeygi H.
dc.contributor.authorButler A.E.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:30:36Z
dc.date.available2020-09-02T22:30:36Z
dc.date.issued2019
dc.identifier10.1002/jcp.27278
dc.identifier.citation234, 3, 2436-2446
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6643
dc.descriptionMany vascular complications are related to exposure of tissues to elevated levels of glucose, a condition that promotes oxidative stress. The primary goal of antidiabetic medication is for normalization of blood glucose. However, antidiabetic medications may have antioxidant effects that go beyond their hypoglycemic influences. Therefore, antidiabetic drugs may be doubly beneficial in preventing diabetic complications. Vascular dysfunction due to uncontrolled diabetes is a serious complication of the disease and one which has a severe impact on quality of life. Readjustment of the oxidative balance in subjects with diabetes, and the positive effects thereof is a topic of intense interest at present. In the current review, we highlight the antioxidant effects of antidiabetic medications which may prevent or delay the onset of vascular dysfunction. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectantidiabetic medications
dc.subjectdiabetes
dc.subjectdiabetic nephropathy (DN)
dc.subjectoxidative stress
dc.subjectvascular dysfunction
dc.subject2,4 thiazolidinedione derivative
dc.subjectantidiabetic agent
dc.subjectbiguanide derivative
dc.subjectdipeptidyl peptidase IV inhibitor
dc.subjectglucagon like peptide 1 receptor agonist
dc.subjectinsulin
dc.subjectsodium glucose cotransporter 2 inhibitor
dc.subjectsulfonylurea derivative
dc.subjectantidiabetic agent
dc.subjectantioxidant
dc.subjectantioxidant activity
dc.subjectdiabetic complication
dc.subjectdiabetic patient
dc.subjectdrug mechanism
dc.subjecthuman
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectReview
dc.subjectvascular disease
dc.subjectcardiovascular disease
dc.subjectdiabetes mellitus
dc.subjectdiabetic angiopathy
dc.subjectdrug effect
dc.subjectglucose blood level
dc.subjectmetabolism
dc.subjectpathology
dc.subjectquality of life
dc.subjectAntioxidants
dc.subjectBlood Glucose
dc.subjectCardiovascular Diseases
dc.subjectDiabetes Mellitus
dc.subjectDiabetic Angiopathies
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.subjectOxidative Stress
dc.subjectQuality of Life
dc.titleAntioxidative potential of antidiabetic agents: A possible protective mechanism against vascular complications in diabetic patients
dc.typeReview


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