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Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways

dc.contributor.authorYaribeygi H.
dc.contributor.authorAtkin S.L.
dc.contributor.authorSimental-Mendía L.E.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:30:35Z
dc.date.available2020-09-02T22:30:35Z
dc.date.issued2019
dc.identifier10.1002/jcp.28315
dc.identifier.citation234, 9, 14873-14882
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6642
dc.descriptionThe incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. The pathways by which resolvins exert this anti-inflammatory effect are unclear. In this review we discuss the evidence showing that resolvins can suppress inflammatory responses via at least five molecular mechanisms through inhibition of the nucleotide-binding oligomerization domain protein 3 inflammasome, inhibition of nuclear factor κB molecular pathways, improvement of oxidative stress, modulation of nitric oxide synthesis/release and prevention of local and systemic leukocytosis. Complete understanding of these molecular pathways is important as this may lead to the development of new effective therapeutic strategies for diabetes and diabetic nephropathy. © 2019 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectdiabetic nephropathy
dc.subjectinflammation
dc.subjectNF-κB
dc.subjectoxidative stress
dc.subjectresolvin D1
dc.subjectresolvin E1
dc.subjectantiinflammatory agent
dc.subjectcryopyrin
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectnitric oxide
dc.subjectplant medicinal product
dc.subjectpolyunsaturated fatty acid
dc.subjectresolvin
dc.subjectunclassified drug
dc.subjectantiinflammatory activity
dc.subjectbiochemistry
dc.subjectbiological activity
dc.subjectclassification
dc.subjectdiabetes mellitus
dc.subjectdiabetic complication
dc.subjectdiabetic nephropathy
dc.subjectdrug efficacy
dc.subjectdrug safety
dc.subjectfatty acid synthesis
dc.subjecthuman
dc.subjectinflammation
dc.subjectleukocytosis
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectReview
dc.subjectrisk
dc.subjectsignal transduction
dc.titleAnti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways
dc.typeReview


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