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Effects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood

dc.contributor.authorVásquez B.
dc.contributor.authorSandoval C.
dc.contributor.authorSmith R.L.
dc.contributor.authordel Sol M.
dc.date.accessioned2020-09-02T22:30:28Z
dc.date.available2020-09-02T22:30:28Z
dc.date.issued2014
dc.identifier.citation7, 8, 4627-4635
dc.identifier.issn19362625
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6603
dc.descriptionThe literature indicates that early rupture of the maternal bond and social isolation are variables involved in social and emotional behaviors and in increase in anxiety, particularly in stressful situations. The liver plays a role in the adaptation to stress, yet the possible morphologic changes that its structure can suffer have been studied very little. Therefore, the aim here was to ascertain, through the model of altering the early mother-infant bond and the late social bond through isolation, the effect on the stereologic characteristics of the liver in adult Sprague-Dawley rats subjected to intermittent chronic stress. Twenty-five newborn female rats were used, distributed into 5 groups, under standardized lactation and feeding conditions. The experimental groups were exposed to early (E1), late (E2), and early-late (E3) adverse experiences and then subjected to intermittent chronic stress in adulthood. The liver of each animal was isolated, and the stereologic characteristics of Nv, Vv, and Sv of the hepatocytes were determined. The results from the experimental groups were significantly higher than those obtained in the control groups. The highest values were found in group E3 (Nv = 4.43 ± 0.89 × 105/mm3, Vv = 68.74 ± 2.01%, Sv = 68.78 ± 3.77 mm2/mm3). Considering these results, the hepatic morphology can be affected by exposure to chronic stress; however, when the individuals have been subjected to previous adverse experiences, the changes are more evident.
dc.language.isoen
dc.publisherE-Century Publishing Corporation
dc.subjectAdverse experience
dc.subjectLiver
dc.subjectMorphology
dc.subjectRat
dc.subjectStress
dc.subjectanimal
dc.subjectcomplication
dc.subjectfemale
dc.subjectliver
dc.subjectmental stress
dc.subjectnewborn
dc.subjectpathology
dc.subjectrat
dc.subjectsocial isolation
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectFemale
dc.subjectLiver
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSocial Isolation
dc.subjectStress, Psychological
dc.titleEffects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood
dc.typeArticle


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