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Inhibiting Pathogen Surface Adherence by Multilayer Polyelectrolyte Films Functionalized with Glucofuranose Derivatives

dc.contributor.authorVillalobos V.
dc.contributor.authorLeiva Á.
dc.contributor.authorRíos H.E.
dc.contributor.authorPavez J.
dc.contributor.authorSilva C.P.
dc.contributor.authorAhmar M.
dc.contributor.authorQueneau Y.
dc.contributor.authorBlamey J.M.
dc.contributor.authorChávez F.P.
dc.contributor.authorUrzúa M.D.
dc.date.accessioned2020-09-02T22:30:25Z
dc.date.available2020-09-02T22:30:25Z
dc.date.issued2018
dc.identifier10.1021/acsami.8b03605
dc.identifier.citation10, 33, 28147-28158
dc.identifier.issn19448244
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6575
dc.descriptionInhibiting pathogenic bacterial adherence on surfaces is an ongoing challenge to prevent the development of biofilms. Multilayer polyelectrolyte films are feasible antibacterial materials. Here, we have designed new films made of carbohydrate polyelectrolytes to obtain antibacterial coatings that prevent biofilm formation. The polyelectrolyte films were constructed from poly(maleic anhydride-alt-styrene) functionalized with glucofuranose derivatives and quaternized poly(4-vinylpyridine) N-alkyl. These films prevent Pseudomonas aeruginosa and Salmonella Typhimurium, two important bacterial contaminants in clinical environments, from adhering to surfaces. When the film was composed of more than 10 layers, the bacterial population was greatly reduced, while the bacteria remaining on the film were morphologically damaged, as atomic force microscopy revealed. The antibacterial capacity of the polyelectrolyte films was determined by the combination of thickness, wettability, surface energy, and most importantly, the conformation that polyelectrolytes adopt the function of nature of the carbohydrate group. This polyelectrolyte film constitutes the first green approach to preventing pathogenic bacterial surface adherence and proliferation without killing the bacterial pathogen. © 2018 American Chemical Society.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectadherence inhibition
dc.subjectantibacterial surfaces
dc.subjectcarbohydrate polyelectrolytes
dc.subjectP. aeruginosa
dc.subjectS. Typhimurium
dc.subjectAtomic force microscopy
dc.subjectBiofilms
dc.subjectCarbohydrates
dc.subjectMultilayers
dc.subjectPolyelectrolytes
dc.subjectSalmonella
dc.subjectStyrene
dc.subjectAntibacterial coatings
dc.subjectAntibacterial materials
dc.subjectBacterial contaminants
dc.subjectClinical environments
dc.subjectPoly(4-vinyl pyridine)
dc.subjectPolyelectrolyte films
dc.subjectPseudomonas aeruginosa
dc.subjectSalmonella typhimurium
dc.subjectMultilayer films
dc.subjectantiinfective agent
dc.subjectpolyelectrolyte
dc.subjectatomic force microscopy
dc.subjectbiofilm
dc.subjectchemistry
dc.subjectsurface property
dc.subjectwettability
dc.subjectAnti-Bacterial Agents
dc.subjectBiofilms
dc.subjectMicroscopy, Atomic Force
dc.subjectPolyelectrolytes
dc.subjectSurface Properties
dc.subjectWettability
dc.titleInhibiting Pathogen Surface Adherence by Multilayer Polyelectrolyte Films Functionalized with Glucofuranose Derivatives
dc.typeArticle


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