Mostrar el registro sencillo del ítem

Connexin and pannexin-based channels in oligodendrocytes: Implications in brain health and disease

dc.contributor.authorVejar S.
dc.contributor.authorOyarzún J.E.
dc.contributor.authorRetamal M.A.
dc.contributor.authorOrtiz F.C.
dc.contributor.authorOrellana J.A.
dc.date.accessioned2020-09-02T22:29:57Z
dc.date.available2020-09-02T22:29:57Z
dc.date.issued2019
dc.identifier10.3389/fncel.2019.00003
dc.identifier.citation13, , -
dc.identifier.issn16625102
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6530
dc.descriptionOligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper synaptic transmission and plasticity at the CNS. The latter requires a fine coordinated intercellular communication with neurons and other glial cell types, including astrocytes. In mammals, tissue synchronization is mainly mediated by connexins and pannexins, two protein families that underpin the communication among neighboring cells through the formation of different plasma membrane channels. At one end, gap junction channels (GJCs; which are exclusively formed by connexins in vertebrates) connect the cytoplasm of contacting cells allowing electrical and metabolic coupling. At the other end, hemichannels and pannexons (which are formed by connexins and pannexins, respectively) communicate the intra- and extracellular compartments, serving as diffusion pathways of ions and small molecules. Here, we briefly review the current knowledge about the expression and function of hemichannels, pannexons and GJCs in oligodendrocytes, as well as the evidence regarding the possible role of these channels in metabolic and synaptic functions at the CNS. In particular, we focus on oligodendrocyte-astrocyte coupling during axon metabolic support and its implications in brain health and disease. © 2019 Vejar, Oyarzún, Retamal, Ortiz and Orellana.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectConnexons
dc.subjectDemyelinating neuropathy
dc.subjectGap junctions
dc.subjectHemichannels
dc.subjectOligodendrocytes
dc.subjectPannexons
dc.subjectconnexin 32
dc.subjectconnexin 43
dc.subjectconnexin 45
dc.subjectconnexin 47
dc.subjectgap junction protein
dc.subjectmembrane protein
dc.subjectpannexon
dc.subjectpurinergic P2X receptor
dc.subjectpurinergic P2X7 receptor
dc.subjecttranscription factor Sox10
dc.subjectunclassified drug
dc.subjectbrain disease
dc.subjectcell communication
dc.subjectcell proliferation
dc.subjectcerebrospinal fluid
dc.subjectdemyelinating disease
dc.subjectdemyelination
dc.subjectelectron microscopy
dc.subjectexperimental autoimmune encephalomyelitis
dc.subjectgap junction
dc.subjectgene expression
dc.subjecthuman
dc.subjectimmunogold labeling
dc.subjectimmunohistochemistry
dc.subjectleukodystrophy
dc.subjectmultiple sclerosis
dc.subjectnerve cell differentiation
dc.subjectnonhuman
dc.subjectoligodendroglia
dc.subjectpathogenesis
dc.subjectprotein expression
dc.subjectReview
dc.subjectsyncytium
dc.subjectvasodilatation
dc.titleConnexin and pannexin-based channels in oligodendrocytes: Implications in brain health and disease
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85064189440.pdf
Tamaño:
3.422Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem