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Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders

dc.contributor.authorUllah M.F.
dc.contributor.authorAhmad A.
dc.contributor.authorBhat S.H.
dc.contributor.authorAbu-Duhier F.M.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:29:52Z
dc.date.available2020-09-02T22:29:52Z
dc.date.issued2019
dc.identifier10.1016/j.neubiorev.2019.04.003
dc.identifier.citation102, , 95-105
dc.identifier.issn01497634
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6493
dc.descriptionThe impact of neurodegenerative disorders in humans has multiple consequences because of the progressive decline in cognitive and physical performances. These disorders have diverse manifestations and are influenced by genetic and lifestyle factors, concurrent health conditions as well as un-modifiable predisposing risk factors, including gender and advanced age. Accumulating evidence indicates a gender-dependent natural bias of neurodegenerative diseases, such as, Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple sclerosis, with the ratio of male to female prevalence as well as the severity of the disease differing significantly between the two sexes. This observation has recently garnered much attention and it is now being realized that understanding the sex as a biological variable in the etiology of the neurodegenerative diseases may advance the status of the pathophysiology and treatment strategies while improving the associated decline in cognitive and functional abilities. This review highlights the influence of gender in neurodegenerative disorders and further discusses the sex-specific pre-determined microenvironments that are critical in predisposing the individuals to such disorders. © 2019 Elsevier Ltd
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectAlzheimer's disease
dc.subjectCognitive impairment
dc.subjectGender bias
dc.subjectHuntington's disease
dc.subjectMultiple sclerosis
dc.subjectNeurodegenerative disorders
dc.subjectParkinson's disease
dc.subjectDNA
dc.subjecthistone
dc.subjectneurotransmitter
dc.subjectsex hormone
dc.subjectAlzheimer disease
dc.subjectastrocyte
dc.subjectbehavior
dc.subjectbrain development
dc.subjectbrain mitochondrion
dc.subjectdegenerative disease
dc.subjectDNA methylation
dc.subjectDNA modification
dc.subjectepigenetics
dc.subjectgender bias
dc.subjectgene
dc.subjecthuman
dc.subjectHuntington chorea
dc.subjectmultiple sclerosis
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectReview
dc.subjectsex difference
dc.subjectAlzheimer disease
dc.subjectbrain
dc.subjectgenetic epigenesis
dc.subjectHuntington chorea
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjectmultiple sclerosis
dc.subjectParkinson disease
dc.subjectphysiology
dc.subjectsex factor
dc.subjectsexual characteristics
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectEpigenesis, Genetic
dc.subjectHumans
dc.subjectHuntington Disease
dc.subjectMitochondria
dc.subjectMultiple Sclerosis
dc.subjectParkinson Disease
dc.subjectSex Characteristics
dc.subjectSex Factors
dc.titleImpact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders
dc.typeReview


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