Mostrar el registro sencillo del ítem

Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease

dc.contributor.authorUddin M.S.
dc.contributor.authorRahman M.A.
dc.contributor.authorKabir M.T.
dc.contributor.authorBehl T.
dc.contributor.authorMathew B.
dc.contributor.authorPerveen A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorBin-Jumah M.N.
dc.contributor.authorAbdel-Daim M.M.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:29:30Z
dc.date.available2020-09-02T22:29:30Z
dc.date.issued2020
dc.identifier10.1002/iub.2324
dc.identifier.citation72, 9, 1843-1855
dc.identifier.issn15216543
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6467
dc.descriptionAge-related cognitive failure is a main devastating incident affecting even healthy people. Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric community. In the pathogenesis of AD, cerebrovascular dysfunction is revealed before the beginning of the cognitive decline. Mounting proof shows a precarious impact of cerebrovascular dysregulation in the development of AD pathology. Recent studies document that the mammalian target of rapamycin (mTOR) acts as a crucial effector of cerebrovascular dysregulation in AD. The mTOR contributes to brain vascular dysfunction and subsequence cerebral blood flow deficits as well as cognitive impairment. Furthermore, mTOR causes the blood–brain barrier (BBB) breakdown in AD models. Inhibition of mTOR hyperactivity protects the BBB integrity in AD. Furthermore, mTOR drives cognitive defect and cerebrovascular dysfunction, which are greatly prevalent in AD, but the central molecular mechanisms underlying these alterations are obscure. This review represents the crucial and current research findings regarding the role of mTOR signaling in cognitive aging and cerebrovascular dysfunction in the pathogenesis of AD. © 2020 International Union of Biochemistry and Molecular Biology
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectAlzheimer's disease
dc.subjectblood–brain barrier
dc.subjectcerebrovascular dysfunction
dc.subjectcognitive aging
dc.subjectmTOR
dc.subjectmammalian target of rapamycin
dc.subjectAlzheimer disease
dc.subjectblood brain barrier
dc.subjectbrain blood flow
dc.subjectcerebrovascular accident
dc.subjectcerebrovascular disease
dc.subjectcognitive aging
dc.subjectenzyme activity
dc.subjecthuman
dc.subjectmolecular pathology
dc.subjectmTOR signaling
dc.subjectnerve cell plasticity
dc.subjectneuropathology
dc.subjectneurovascular coupling
dc.subjectnonhuman
dc.subjectReview
dc.titleMultifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85085600811.pdf
Tamaño:
2.791Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem