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Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology

dc.contributor.authorUddin M.S.
dc.contributor.authorAl Mamun A.
dc.contributor.authorKabir M.T.
dc.contributor.authorJakaria M.
dc.contributor.authorMathew B.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:29:28Z
dc.date.available2020-09-02T22:29:28Z
dc.date.issued2019
dc.identifier10.1007/s12035-018-1420-2
dc.identifier.citation56, 7, 4925-4944
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6460
dc.descriptionMedicinal plants are the backbone of modern medicine. In recent times, there is a great urge to discover nootropic medicinal plants to reverse cognitive dysfunction owing to their less adverse effects. Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by the inevitable loss of cognitive function, memory and language impairment, and behavioral disturbances, which turn into gradually more severe. Alzheimer’s has no current cure, but symptomatic treatments are available and research continues. The number of patients suffering from AD continues to rise and today, there is a worldwide effort under study to find better ways to alleviate Alzheimer’s pathogenesis. In this review, the nootropic and anti-Alzheimer’s potentials of 6 medicinal plants (i.e., Centella asiatica, Clitoria ternatea, Crocus sativus, Terminalia chebula, Withania somnifera, and Asparagus racemosus) were explored through literature review. This appraisal focused on available information about neuroprotective and anti-Alzheimer’s use of these plants and their respective bioactive compounds/metabolites and associated effects in animal models and consequences of its use in human as well as proposed molecular mechanisms. This review progresses our existing knowledge to reveal the promising linkage of traditional medicine to halt AD pathogenesis. This analysis also avowed a new insight to search the promising anti-Alzheimer’s drugs. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAlzheimer’s disease
dc.subjectCognitive enhancers
dc.subjectMedicinal plants
dc.subjectNeurofibrillary tangles
dc.subjectNootropics
dc.subjectSenile plaques
dc.subjectAsparagus racemosus extract
dc.subjectCentella asiatica extract
dc.subjectcholinesterase inhibitor
dc.subjectClitoria ternatea extract
dc.subjectCrocus sativus extract
dc.subjectnootropic agent
dc.subjectplant extract
dc.subjectTerminalia chebula extract
dc.subjectunclassified drug
dc.subjectWithania somnifera extract
dc.subjectnootropic agent
dc.subjectplant extract
dc.subjectAlzheimer disease
dc.subjectantioxidant activity
dc.subjectAsparagus racemosus
dc.subjectbiological activity
dc.subjectCentella asiatica
dc.subjectClitoria ternatea
dc.subjectcognition
dc.subjectCrocus sativus
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjecthuman
dc.subjectlearning
dc.subjectmedicinal plant
dc.subjectmemory
dc.subjectmolecular interaction
dc.subjectneurofibrillary tangle
dc.subjectneuropathology
dc.subjectneuropharmacology
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectpsychoactive plant
dc.subjectReview
dc.subjectTerminalia chebula
dc.subjecttranquilizing activity
dc.subjectWithania somnifera
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectisolation and purification
dc.subjectpathology
dc.subjectprocedures
dc.subjectrandomized controlled trial (topic)
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectHumans
dc.subjectNootropic Agents
dc.subjectPlant Extracts
dc.subjectPlants, Medicinal
dc.subjectRandomized Controlled Trials as Topic
dc.titleNootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology
dc.typeReview


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