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Porous Nanogold/Polyurethane Scaffolds with Improved Antibiofilm, Mechanical, and Thermal Properties and with Reduced Effects on Cell Viability: A Suitable Material for Soft Tissue Applications

dc.contributor.authorTamayo L.
dc.contributor.authorAcuña D.
dc.contributor.authorRiveros A.L.
dc.contributor.authorKogan M.J.
dc.contributor.authorAzócar M.I.
dc.contributor.authorPáez M.
dc.contributor.authorLeal M.
dc.contributor.authorUrzúa M.
dc.contributor.authorCerda E.
dc.date.accessioned2020-09-02T22:29:28Z
dc.date.available2020-09-02T22:29:28Z
dc.date.issued2018
dc.identifier10.1021/acsami.8b02347
dc.identifier.citation10, 16, 13361-13372
dc.identifier.issn19448244
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6459
dc.descriptionThe use of implants carries on a series of problems, among them infections, poor biocompatibility, high levels of cytotoxicity, and significant mechanical differences between implants and host organs that promote stress shielding effects. These problems indicate that the materials used to make implants must meet essential requirements and high standards for implantations to be successful. In this work, we present the synthesis, characterization and evaluation of the antibiofilm, mechanical, and thermal properties, and cytotoxic effect of a nanocomposite-based scaffold on polyurethane (PU) and gold nanoparticles (AuNPs) for soft tissue applications. The effect of the quantity of AuNPs on the antibacterial activity of nanocomposite scaffolds was evaluated against Staphylococcus epidermidis and Klebsiella spp., with a resulting 99.99% inhibition of both bacteria using a small quantity of nanoparticles. Cytotoxicity was evaluated with the T10 1/2 test against fibroblast cells. The results demonstrated that porous nanogold/PU scaffolds have no toxic effects on fibroblast cells to the 5 day exposition. With respect to mechanical properties, stress-strain curves showed that the compressive modulus and yield strength of PU scaffolds were significantly enhanced by AuNPs (by at least 10 times). This is due to changes in the arrangement of hard segments of PU, which increase the stiffness of the polymer. Thermogravimetric analysis showed that the degradation onset temperature rises with an increase in the quantity of AuNPs. These properties and characteristics demonstrate that porous nanogold/PU scaffolds are suitable material for use in soft tissue implants. © 2018 American Chemical Society.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectantibiofilm
dc.subjectbiomaterials
dc.subjectgold nanoparticles
dc.subjectmechanical properties
dc.subjectnon-cytotoxic
dc.subjectporous scaffolds
dc.subjectBacteria
dc.subjectBiocompatibility
dc.subjectBiomaterials
dc.subjectBiomechanics
dc.subjectCell culture
dc.subjectCytotoxicity
dc.subjectFiber optic sensors
dc.subjectFibroblasts
dc.subjectGold compounds
dc.subjectGold nanoparticles
dc.subjectMechanical properties
dc.subjectMetal nanoparticles
dc.subjectNanocomposites
dc.subjectStrain
dc.subjectStress-strain curves
dc.subjectSynthesis (chemical)
dc.subjectThermodynamic properties
dc.subjectThermogravimetric analysis
dc.subjectTissue
dc.subjectAnti-bacterial activity
dc.subjectAnti-biofilm
dc.subjectCompressive moduli
dc.subjectCytotoxic
dc.subjectCytotoxic effects
dc.subjectNanocomposite scaffolds
dc.subjectPorous scaffold
dc.subjectStaphylococcus epidermidis
dc.subjectScaffolds (biology)
dc.subjectbiomaterial
dc.subjectgold
dc.subjectmetal nanoparticle
dc.subjectpolyurethan
dc.subjectcell survival
dc.subjectchemistry
dc.subjectporosity
dc.subjecttissue engineering
dc.subjecttissue scaffold
dc.subjectBiocompatible Materials
dc.subjectCell Survival
dc.subjectGold
dc.subjectMetal Nanoparticles
dc.subjectPolyurethanes
dc.subjectPorosity
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.titlePorous Nanogold/Polyurethane Scaffolds with Improved Antibiofilm, Mechanical, and Thermal Properties and with Reduced Effects on Cell Viability: A Suitable Material for Soft Tissue Applications
dc.typeArticle


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