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Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen

dc.contributor.authorToro-Urrego N.
dc.contributor.authorVesga-Jiménez D.J.
dc.contributor.authorHerrera M.I.
dc.contributor.authorLuaces J.P.
dc.contributor.authorCapani F.
dc.date.accessioned2020-09-02T22:29:18Z
dc.date.available2020-09-02T22:29:18Z
dc.date.issued2019
dc.identifier10.2174/1570159X17666181206101314
dc.identifier.citation17, 9, 874-890
dc.identifier.issn1570159X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6405
dc.descriptionHypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia. ©2019 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers
dc.subjectCombined therapies
dc.subjectHypoxic-ischemic brain injury
dc.subjectNeuroprotective treatments
dc.subjectSelective estrogen receptor modulators
dc.subjectSelective tissue estrogenic activity regulators
dc.subjectTherapeutic hypothermia
dc.subjectestradiol
dc.subjectestrogen derivative
dc.subjectneuroprotective agent
dc.subjectreactive oxygen metabolite
dc.subjectselective estrogen receptor modulator
dc.subjectselective tissue estrogenic activity regulator
dc.subjectunclassified drug
dc.subjectestrogen
dc.subjectestrogen receptor
dc.subjectastrocyte
dc.subjectbrain damage
dc.subjectcell death
dc.subjectendothelium cell
dc.subjectexcitotoxicity
dc.subjectglia cell
dc.subjecthuman
dc.subjecthypothermia
dc.subjecthypoxic ischemic encephalopathy
dc.subjectin vitro study
dc.subjectinduced hypothermia
dc.subjectmicroglia
dc.subjectnervous system inflammation
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectReview
dc.subjectanimal
dc.subjecthypoxic ischemic encephalopathy
dc.subjectinduced hypothermia
dc.subjectmetabolism
dc.subjectAnimals
dc.subjectEstrogens
dc.subjectHumans
dc.subjectHypothermia, Induced
dc.subjectHypoxia-Ischemia, Brain
dc.subjectNeuroprotective Agents
dc.subjectReceptors, Estrogen
dc.titleNeuroprotective role of hypothermia in hypoxic-ischemic brain injury: Combined therapies using estrogen
dc.typeReview


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