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Testosterone protects mitochondrial function and regulates neuroglobin expression in astrocytic cells exposed to glucose deprivation

dc.contributor.authorToro-Urrego N.
dc.contributor.authorGarcia-Segura L.M.
dc.contributor.authorEcheverria V.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:29:17Z
dc.date.available2020-09-02T22:29:17Z
dc.date.issued2016
dc.identifier10.3389/fnagi.2016.00152
dc.identifier.citation8, JUN, -
dc.identifier.issn16634365
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6403
dc.descriptionTestosterone is a hormone that has been shown to confer neuroprotection from different insults affecting the central nervous system (CNS). Testosterone induces this protection by different mechanisms that include the activation of anti-apoptotic pathways that are directly implicated in neuronal survival. However, little attention has been devoted to its actions on glial cells. In the present study, we have assessed whether testosterone exerts protection in a human astrocyte cell model, the T98G cells. Our results indicate that testosterone improves cell survival and mitochondrial membrane potential and reduces nuclear fragmentation and reactive oxygen species (ROS) generation. These effects were accompanied by a positive regulation of neuroglobin, an oxygen-binding and sensor protein, which may serve as a regulator of ROS and nitrogen reactive species (NOS), and these protective effects of testosterone may be at least in part mediated by estradiol and DHT. In conclusion, these findings suggest that astroglia may mediate some of the protective actions of testosterone in the brain upon pathological conditions. © 2016 Toro-Urrego, Garcia-Segura, Echeverria and Barreto.
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectBrain
dc.subjectGlucose deprivation
dc.subjectMitochondria
dc.subjectNeuroglobin
dc.subjectNeuroprotection
dc.subjectTestosterone
dc.subjectestradiol
dc.subjectglucose
dc.subjecthemoprotein
dc.subjectneuroglobin
dc.subjectnitrogen
dc.subjectreactive oxygen metabolite
dc.subjecttestosterone
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell structure
dc.subjectcell survival
dc.subjectcell viability
dc.subjectcentral nervous system
dc.subjectcontrolled study
dc.subjectglia cell
dc.subjecthuman
dc.subjectmacroglia
dc.subjectmitochondrial membrane potential
dc.subjectmitochondrial permeability
dc.subjectmitochondrion
dc.subjectnerve cell
dc.subjectnonhuman
dc.subjectoxygen affinity
dc.subjectprotein expression
dc.titleTestosterone protects mitochondrial function and regulates neuroglobin expression in astrocytic cells exposed to glucose deprivation
dc.typeArticle


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