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Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help

dc.contributor.authorTomé-Carneiro J.
dc.contributor.authorFernández-Alonso N.
dc.contributor.authorTomás-Zapico C.
dc.contributor.authorVisioli F.
dc.contributor.authorIglesias-Gutierrez E.
dc.contributor.authorDávalos A.
dc.date.accessioned2020-09-02T22:29:16Z
dc.date.available2020-09-02T22:29:16Z
dc.date.issued2018
dc.identifier10.1016/j.phrs.2018.04.003
dc.identifier.citation132, , 21-32
dc.identifier.issn10436618
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6396
dc.descriptionThe possibility that diet-derived miRNAs survive the gastrointestinal tract and exert biological effects in target cells is triggering considerable research in the potential abilities of alimentary preventive and therapeutic approaches. Many validation attempts have been carried out and investigators disagree on several issues. The barriers exogenous RNAs must surpass are harsh and adequate copies must reach target cells for biological actions to be carried out. This prospect opened a window for previously unlikely scenarios concerning exogenous non-coding RNAs, such as a potential role for breast milk microRNAs in infants’ development and maturation. This review is focused on the thorny path breast milk miRNAs face towards confirmation as relevant role players in infants’ development and maturation, taking into consideration the research carried out so far on the uptake, gastrointestinal barriers and potential biological effects of diet-derived miRNAs. We also discuss the future pharmacological and pharma-nutritional consequences of appropriate miRNAs research. © 2018 Elsevier Ltd
dc.language.isoen
dc.publisherAcademic Press
dc.subjectBreast milk
dc.subjectDiet
dc.subjectExogenous
dc.subjectExosome
dc.subjectmiRNA
dc.subjectlipid
dc.subjectmicroRNA
dc.subjectmicroRNA 125b
dc.subjectmicroRNA 141 3p
dc.subjectmicroRNA 146b
dc.subjectmicroRNA 146b 5p
dc.subjectmicroRNA 148a
dc.subjectmicroRNA 155
dc.subjectmicroRNA 156a
dc.subjectmicroRNA 159
dc.subjectmicroRNA 159a
dc.subjectmicroRNA 168a
dc.subjectmicroRNA 169a
dc.subjectmicroRNA 17
dc.subjectmicroRNA 181a
dc.subjectmicroRNA 181b
dc.subjectmicroRNA 182 5p
dc.subjectmicroRNA 191 5p
dc.subjectmicroRNA 200a 3p
dc.subjectmicroRNA 21
dc.subjectmicroRNA 22 3p
dc.subjectmicroRNA 223
dc.subjectmicroRNA 26a 5p
dc.subjectmicroRNA 2911
dc.subjectmicroRNA 29a 3p
dc.subjectmicroRNA 30b 5p
dc.subjectmicroRNA 30d 5p
dc.subjectmicroRNA 92
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectuntranslated RNA
dc.subjectlipid
dc.subjectmicroRNA
dc.subjectbreast milk
dc.subjectchild development
dc.subjectcolostrum
dc.subjectencapsulation
dc.subjectgene function
dc.subjecthuman
dc.subjectimmune system
dc.subjectlactation
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectReview
dc.subjectRNA sequence
dc.subjectRNA stability
dc.subjectRNA transport
dc.subjectsequence analysis
dc.subjectanimal
dc.subjectbioavailability
dc.subjectchild development
dc.subjectimmunology
dc.subjectnewborn
dc.subjectAnimals
dc.subjectBiological Availability
dc.subjectChild Development
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectLipids
dc.subjectMicroRNAs
dc.subjectMilk, Human
dc.titleBreast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help
dc.typeReview


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