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Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

dc.contributor.authorTomé-Carneiro J.
dc.contributor.authorCrespo M.C.
dc.contributor.authorIglesias-Gutierrez E.
dc.contributor.authorMartín R.
dc.contributor.authorGil-Zamorano J.
dc.contributor.authorTomas-Zapico C.
dc.contributor.authorBurgos-Ramos E.
dc.contributor.authorCorrea C.
dc.contributor.authorGómez-Coronado D.
dc.contributor.authorLasunción M.A.
dc.contributor.authorHerrera E.
dc.contributor.authorVisioli F.
dc.contributor.authorDávalos A.
dc.date.accessioned2020-09-02T22:29:16Z
dc.date.available2020-09-02T22:29:16Z
dc.date.issued2016
dc.identifier10.1016/j.jnutbio.2016.05.009
dc.identifier.citation34, , 146-155
dc.identifier.issn09552863
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6395
dc.descriptionDietary microRNAs (miRNAs) modulation could be important for health and wellbeing. Part of the healthful activities of polyphenols might be due to a modulation of miRNAs' expression. Among the most biologically active polyphenols, hydroxytyrosol (HT) has never been studied for its actions on miRNAs. We investigated whether HT could modulate the expression of miRNAs in vivo. We performed an unbiased intestinal miRNA screening in mice supplemented (for 8 weeks) with nutritionally relevant amounts of HT. HT modulated the expression of several miRNAs. Analysis of other tissues revealed consistent HT-induced modulation of only few miRNAs. Also, HT administration increased triglycerides levels. Acute treatment with HT and in vitro experiments provided mechanistic insights. The HT-induced expression of one miRNA was confirmed in healthy volunteers supplemented with HT in a randomized, double-blind and placebo-controlled trial. HT consumption affects specific miRNAs' expression in rodents and humans. Our findings suggest that the modulation of miRNAs' action through HT consumption might partially explain its healthful activities and might be pharmanutritionally exploited in current therapies targeting endogenous miRNAs. However, the effects of HT on triglycerides warrant further investigations. © 2016 Elsevier Inc.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectDietary Supplementation
dc.subjectHydroxytyrosol
dc.subjectIntestine
dc.subjectLipids
dc.subjectMiRNAs
dc.subjectCD36 antigen
dc.subjectcholesterol
dc.subjectCXCL13 chemokine
dc.subjectdual specificity phosphatase 6
dc.subjectglutathione transferase A3
dc.subjecthydroxytyrosol
dc.subjectinterleukin 33
dc.subjectmessenger RNA
dc.subjectmicroRNA
dc.subjectmicroRNA 1247 5p
dc.subjectmicroRNA 135a 1 3p
dc.subjectmicroRNA 1898
dc.subjectmicroRNA 193a 5p
dc.subjectmicroRNA 196b 3p
dc.subjectmicroRNA 1982 5p
dc.subjectmicroRNA 346 5p
dc.subjectmicroRNA 483 3p
dc.subjectmicroRNA 491 3p
dc.subjectphospholipid
dc.subjectplacebo
dc.subjectpyruvate dehydrogenase kinase 4
dc.subjecttriacylglycerol
dc.subjectunclassified drug
dc.subject3,4-dihydroxyphenylethanol
dc.subjectmicroRNA
dc.subjectphenethyl alcohol
dc.subjectacute drug administration
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectcrossover procedure
dc.subjectdiet supplementation
dc.subjectdouble blind procedure
dc.subjectdown regulation
dc.subjectgene expression
dc.subjectgene interaction
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman experiment
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectlipid metabolism
dc.subjectmale
dc.subjectnonhuman
dc.subjectnormal human
dc.subjectoxidative stress
dc.subjectphospholipid blood level
dc.subjectrandomized controlled trial
dc.subjectrat
dc.subjecttreatment duration
dc.subjecttriacylglycerol blood level
dc.subjectupregulation
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectantibody specificity
dc.subjectC57BL mouse
dc.subjectcell culture
dc.subjectcell line
dc.subjectclinical trial
dc.subjectcomparative study
dc.subjectcytology
dc.subjectdietary supplement
dc.subjectintestine mucosa
dc.subjectmetabolism
dc.subjectmononuclear cell
dc.subjectorganoid
dc.subjectsmall intestine
dc.subjecttissue culture technique
dc.subjectAnimals
dc.subjectCell Line
dc.subjectCells, Cultured
dc.subjectCross-Over Studies
dc.subjectDietary Supplements
dc.subjectDouble-Blind Method
dc.subjectHumans
dc.subjectIntestinal Mucosa
dc.subjectIntestine, Small
dc.subjectLeukocytes, Mononuclear
dc.subjectMale
dc.subjectMice, Inbred C57BL
dc.subjectMicroRNAs
dc.subjectOrgan Specificity
dc.subjectOrganoids
dc.subjectPhenylethyl Alcohol
dc.subjectTissue Culture Techniques
dc.titleHydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans
dc.typeArticle


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