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Effect of Polymer Micelles on Antifungal Activity of Geranylorcinol Compounds against Botrytis cinerea

dc.contributor.authorTaborga L.
dc.contributor.authorDíaz K.
dc.contributor.authorOlea A.F.
dc.contributor.authorReyes-Bravo P.
dc.contributor.authorFlores M.E.
dc.contributor.authorPeña-Cortés H.
dc.contributor.authorEspinoza L.
dc.date.accessioned2020-09-02T22:29:16Z
dc.date.available2020-09-02T22:29:16Z
dc.date.issued2015
dc.identifier10.1021/acs.jafc.5b01920
dc.identifier.citation63, 31, 6890-6896
dc.identifier.issn00218561
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6393
dc.descriptionHerein, we explore the potential use of two micelle-forming block copolymers, i.e., Pluronic F-127 and poly(ethylene oxide)-b-poly(caprolactone), for application of fungicide agents. The polymer effect on the in vitro fungicide activity of a series of geranyl orcinol derivatives against Botrytis cinerea has been assessed. The results show that, for all test compounds, the incorporation into micelles, formed by Pluronic F-127, produces a great enhancement of the inhibitory effect on the growth of B. cinerea. For some compounds, at the lowest tested concentration (50 ppm), the percentage of inhibition increases significantly (from 0-10 to 80-90%) when the application is made using a polymer solution instead of an ethanol/water mixture. The synthesis and structural determination of a series of eight geranylphenols/diacetates, which were used as fungicide agents, are also discussed. These results suggest that polymer micelles are promising systems for application of crop-protecting agents. © 2015 American Chemical Society.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectantifungal
dc.subjectBotrytis cinerea
dc.subjectlinear geranylphenols
dc.subjectpolymer micelles
dc.subjectstructural determination
dc.subjectBlock copolymers
dc.subjectEthylene
dc.subjectFungicides
dc.subjectPolyethylene oxides
dc.subjectAnti-fungal
dc.subjectBotrytis cinerea
dc.subjectlinear geranylphenols
dc.subjectPolymer micelles
dc.subjectStructural determination
dc.subjectMicelles
dc.subjectBotryotinia fuckeliana
dc.subjectdrug carrier
dc.subjectfungicide
dc.subjectmicelle
dc.subjectorcinol
dc.subjectpoloxamer
dc.subjectresorcinol derivative
dc.subjectBotrytis
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectgrowth, development and aging
dc.subjectmicelle
dc.subjectBotrytis
dc.subjectDrug Carriers
dc.subjectFungicides, Industrial
dc.subjectMicelles
dc.subjectPoloxamer
dc.subjectResorcinols
dc.titleEffect of Polymer Micelles on Antifungal Activity of Geranylorcinol Compounds against Botrytis cinerea
dc.typeArticle


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