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Ru(II)-Catalyzed Regioselective Hydroxymethylation of β-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening

dc.contributor.authorTokala R.
dc.contributor.authorBora D.
dc.contributor.authorSana S.
dc.contributor.authorNachtigall F.M.
dc.contributor.authorSantos L.S.
dc.contributor.authorShankaraiah N.
dc.date.accessioned2020-09-02T22:29:15Z
dc.date.available2020-09-02T22:29:15Z
dc.date.issued2019
dc.identifier10.1021/acs.joc.9b00454
dc.identifier.citation84, 9, 5504-5513
dc.identifier.issn00223263
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6389
dc.descriptionA Ru(II)-catalyzed regioselective C-H activation toward hydroxymethylation of β-carbolines and isoquinolines as effective directing groups has been developed, and the mechanism was probed by using online electrospray ionization-tandem mass spectrometry. The introduction of the hydroxymethyl group in the biologically relevant molecules routed via C-H functionalization remains an important task. Gratifyingly, this protocol draws attention to the regioselective formation of monohydroxymethylated β-carboline/isoquinoline products exclusively. © 2019 American Chemical Society.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.titleRu(II)-Catalyzed Regioselective Hydroxymethylation of β-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening
dc.typeArticle


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