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Pharmacological aspects of neuro-immune interactions

dc.contributor.authorTarasov V.V.
dc.contributor.authorKudryashov N.V.
dc.contributor.authorChubarev V.N.
dc.contributor.authorKalinina T.S.
dc.contributor.authorBarreto G.E.
dc.contributor.authorAshraf G.M.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:29:14Z
dc.date.available2020-09-02T22:29:14Z
dc.date.issued2018
dc.identifier10.2174/1381612823666170829135115
dc.identifier.citation24, 1, 15-21
dc.identifier.issn13816128
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6378
dc.descriptionThe use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacological effects of psychotropic drugs possessing immunomodulatory and/or antiviral properties have shown a correlation between central effects of examined drugs associated with the impact on the processes of neurogenesis of adult brain and survival of neurons, and their ability to alter levels of key proinflammatory cytokines. The changes that occur as a result of the influence of pharmacological agents at one of the systems should inevitably lead to the functional reorganization at another. Integrative mechanisms underlying the neuro-immune interactions may explain the "pleiotropic" pharmacological effects of some antiviral and immunomodulatory drugs. Amantadine, which was originally considered as an antiviral agent, was approved as anti-parkinsonic drug after its wide medical use. The prolonged administration of interferon alpha caused depression in 30-45% of patients, thus limiting its clinical use. The antiviral drug “Oseltamivir” may provoke the development of central side effects, including abnormal behavior, delirium, impaired perception and suicides. Anti-herpethetical drug “Panavir” shows pronounced neuroprotective properties. The purpose of this review is to analyze the experimental and clinical data related to central effects of drugs with antiviral or/and immunotropic activity, and to discover the relationship of these effects with changes in reactivity of immune system and proinflammatory response. © 2018 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAmantadine
dc.subjectAmitriptyline
dc.subjectInterferon
dc.subjectNeuro-immune interaction
dc.subjectNeurogenesis
dc.subjectOseltamivir
dc.subjectPanavir
dc.subjectSemax
dc.subjectalpha interferon
dc.subjectamantadine
dc.subjectamitriptyline
dc.subjectantivirus agent
dc.subjectcytokine
dc.subjectimmunomodulating agent
dc.subjectoseltamivir
dc.subjectpanavir
dc.subjectpeptide derivative
dc.subjectpsychotropic agent
dc.subjectsemax
dc.subjectunclassified drug
dc.subjectoseltamivir
dc.subjectprobucol
dc.subjectantiviral activity
dc.subjectbehavior disorder
dc.subjectbrain nerve cell
dc.subjectcell survival
dc.subjectclinical pharmacology
dc.subjectdelirium
dc.subjectdepression
dc.subjectdrug activity
dc.subjectdrug analysis
dc.subjectdrug approval
dc.subjectdrug design
dc.subjectdrug efficacy
dc.subjectdrug indication
dc.subjectdrug mechanism
dc.subjectdrug safety
dc.subjecthuman
dc.subjectimmune system
dc.subjectimmunomodulation
dc.subjectinflammation
dc.subjectnervous system development
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectperception disorder
dc.subjectpriority journal
dc.subjectReview
dc.subjectside effect
dc.subjectsuicide
dc.subjectanimal
dc.subjectdrug effect
dc.subjectimmunology
dc.subjectimmunomodulation
dc.subjectnervous system
dc.subjectAnimals
dc.subjectAntiviral Agents
dc.subjectHumans
dc.subjectImmune System
dc.subjectImmunomodulation
dc.subjectNervous System
dc.subjectOseltamivir
dc.subjectProbucol
dc.titlePharmacological aspects of neuro-immune interactions
dc.typeReview


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