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Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment

dc.contributor.authorTapia-Rojas C.
dc.contributor.authorCarvajal F.J.
dc.contributor.authorMira R.G.
dc.contributor.authorArce C.
dc.contributor.authorLerma-Cabrera J.M.
dc.contributor.authorOrellana J.A.
dc.contributor.authorCerpa W.
dc.contributor.authorQuintanilla R.A.
dc.date.accessioned2020-09-02T22:29:14Z
dc.date.available2020-09-02T22:29:14Z
dc.date.issued2018
dc.identifier10.1007/s12035-017-0613-4
dc.identifier.citation55, 5, 4473-4491
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6373
dc.descriptionIn the young population, binge drinking is a pattern of problematic alcohol consumption, characterized by a short period of heavy drinking followed by abstinence which is frequently repeated over time. This drinking pattern is associated with mental problems, use of other drugs, and an increased risk of excessive alcohol intake during adulthood. However, little is known about the effects of binge drinking on brain function in adolescents and its neurobiological impact during the adulthood. In the present study, we evaluated the effects of alcohol on hippocampal memory, synaptic plasticity, and mitochondrial function in adolescent rats after a binge drinking episode in vivo. These effects were analyzed at 1, 3, or 7 weeks post alcohol exposure. Our results showed that binge-like ethanol pre-treated (BEP) rats exhibited early alterations in learning and memory tests accompanied by an impairment of synaptic plasticity that was total and partially compensated, respectively. These changes could be attributed to a rapid increase in oxidative damage and a late inflammatory response induced by post ethanol exposure. Additionally, BEP alters the regulation of mitochondrial dynamics and modifies the expression of mitochondrial permeability transition pore (mPTP) components, such as cyclophilin D (Cyp-D) and the voltage-dependent anion channel (VDAC). These mitochondrial structural changes result in the impairment of mitochondrial bioenergetics, decreasing ATP production progressively until adulthood. These results strongly suggest that teenage alcohol binge drinking impairs the function of the adult hippocampus including memory and synaptic plasticity as a consequence of the mitochondrial damage induced by alcohol and that the recovery of hippocampal function could implicate the activation of alternative pathways that fail to reestablish mitochondrial function. © 2017, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAlcohol
dc.subjectBinge drinking
dc.subjectMitochondria
dc.subjectOxidative stress
dc.subjectSynaptic dysfunction
dc.subjectadenosine triphosphate
dc.subjectalcohol
dc.subjectcyclophilin D
dc.subjectmitochondrial permeability transition pore
dc.subjectvoltage dependent anion channel
dc.subjectadenosine triphosphate
dc.subjectcarrier protein
dc.subjectGA binding protein
dc.subjectGabpa protein, rat
dc.subjectmitochondrial permeability transition pore
dc.subjectadolescent
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbinge drinking
dc.subjectbioenergy
dc.subjectbrain function
dc.subjectcontrolled study
dc.subjecthippocampus
dc.subjecthuman
dc.subjectin vivo study
dc.subjectinflammation
dc.subjectlearning test
dc.subjectmale
dc.subjectmemory
dc.subjectmemory test
dc.subjectmitochondrial dynamics
dc.subjectmitochondrion
dc.subjectnerve cell plasticity
dc.subjectnonhuman
dc.subjectanimal
dc.subjectbinge drinking
dc.subjectbiosynthesis
dc.subjectbrain
dc.subjectcognition
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectrat
dc.subjectSprague Dawley rat
dc.subjectsynaptic transmission
dc.subjecttask performance
dc.subjectAdenosine Triphosphate
dc.subjectAdolescent
dc.subjectAnimals
dc.subjectBinge Drinking
dc.subjectBrain
dc.subjectCognition
dc.subjectGA-Binding Protein Transcription Factor
dc.subjectHippocampus
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectMitochondria
dc.subjectMitochondrial Dynamics
dc.subjectMitochondrial Membrane Transport Proteins
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSynaptic Transmission
dc.subjectTask Performance and Analysis
dc.titleAdolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
dc.typeArticle


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