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Impact of number of episodes on neurocognitive trajectory in bipolar disorder patients: A 5-year follow-up study

dc.contributor.authorSánchez-Morla E.M.
dc.contributor.authorLópez-Villarreal A.
dc.contributor.authorJiménez-López E.
dc.contributor.authorAparicio A.I.
dc.contributor.authorMartínez-Vizcaíno V.
dc.contributor.authorRoberto R.-J.
dc.contributor.authorVieta E.
dc.contributor.authorSantos J.-L.
dc.date.accessioned2020-09-02T22:29:13Z
dc.date.available2020-09-02T22:29:13Z
dc.date.issued2019
dc.identifier10.1017/S0033291718001885
dc.identifier.citation49, 8, 1299-1307
dc.identifier.issn00332917
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6370
dc.descriptionBackground The neurocognitive trajectory in bipolar disorder (BD) is variable, with controversial findings, and most evidence come from cross-sectional studies. We aimed to examine the course of neurocognitive functioning in a sample of euthymic BD patients in comparison with a control group during a 5-year follow-up.Methods Ninety-nine euthymic bipolar patients and 40 healthy controls were assessed using a comprehensive neurocognitive battery (six neurocognitive domains) at baseline (T1) and then at 5-year follow-up (T2) in a longitudinal study.Results No evidence of a progression in neurocognitive dysfunction was found either in cognitive composite index or in any of the neurocognitive domains for the whole cohort. However, there was a negative correlation between number of manic episodes and hospitalisations due to manic episodes and change in neurocognitive composite index (NCI) during the follow-up. Moreover, patients with higher number of manic and hypomanic episodes have a greater decrease in NCI, working memory and visual memory. History of psychotic symptoms was not related to the trajectory of neurocognitive impairment.Conclusions Our results suggest that, although the progression of cognitive decline is not a general rule in BD, BD patients who have a greater number of manic or hypomanic episodes may constitute a subgroup characterised by the progression of neurocognitive impairment. Prevention of manic and hypomanic episodes could have a positive impact on the trajectory of cognitive function. © 2018 Cambridge University Press.
dc.language.isoen
dc.publisherCambridge University Press
dc.subjectBipolar disorder
dc.subjectcognition
dc.subjectfollow-up
dc.subjectneuroprogression
dc.subjectadult
dc.subjectbipolar disorder
dc.subjectcase control study
dc.subjectcognition
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectneuropsychological test
dc.subjectprospective study
dc.subjectpsychology
dc.subjectpsychosis
dc.subjectregression analysis
dc.subjectshort term memory
dc.subjectAdult
dc.subjectBipolar Disorder
dc.subjectCase-Control Studies
dc.subjectCognition
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectMale
dc.subjectMemory, Short-Term
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectProspective Studies
dc.subjectPsychotic Disorders
dc.subjectRegression Analysis
dc.titleImpact of number of episodes on neurocognitive trajectory in bipolar disorder patients: A 5-year follow-up study
dc.typeArticle


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