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Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia

dc.contributor.authorSánchez-Domínguez B.
dc.contributor.authorBullón P.
dc.contributor.authorRomán-Malo L.
dc.contributor.authorMarín-Aguilar F.
dc.contributor.authorAlcocer-Gómez E.
dc.contributor.authorCarrión A.M.
dc.contributor.authorSánchez-Alcazar J.A.
dc.contributor.authorCordero M.D.
dc.date.accessioned2020-09-02T22:28:50Z
dc.date.available2020-09-02T22:28:50Z
dc.date.issued2015
dc.identifier10.1016/j.mito.2015.01.010
dc.identifier.citation21, , 69-75
dc.identifier.issn15677249
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6364
dc.descriptionFibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress, mitochondrial dysfunction and inflammation may have a role in the pathophysiology of fibromyalgia. Despite several skin-related symptoms accompanied by small fiber neuropathy have been studied in FM, these mitochondrial changes have not been yet studied in this tissue. Skin biopsies from patients showed a significant mitochondrial dysfunction with reduced mitochondrial chain activities and bioenergetics levels and increased levels of oxidative stress. These data were related to increased levels of inflammation and correlated with pain, the principal symptom of FM. All these parameters have shown a role in peripheral nerve damage which has been observed in FM as a possible responsible to allodynia. Our findings may support the role of oxidative stress, mitochondrial dysfunction and inflammation as interdependent events in the pathophysiology of FM with a special role in the peripheral alterations. © 2015 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier
dc.subjectFibromyalgia
dc.subjectInflammation
dc.subjectMitochondrial dysfunction
dc.subjectOxidative stress
dc.subjectadenosine triphosphate
dc.subjectcytochrome c oxidase
dc.subjectmitochondrial DNA
dc.subjectmitochondrial protein
dc.subjectreduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone)
dc.subjectsuccinate dehydrogenase (ubiquinone)
dc.subjecttumor necrosis factor alpha
dc.subjectubidecarenone
dc.subjectubiquinol cytochrome c reductase
dc.subjectadult
dc.subjectArticle
dc.subjectbioenergy
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisorders of mitochondrial functions
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectfibromyalgia
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectinflammation
dc.subjectmiddle aged
dc.subjectoxidative stress
dc.subjectpathogenesis
dc.subjectperipheral nerve injury
dc.subjectprotein expression
dc.subjectskin biopsy
dc.subjectbiopsy
dc.subjectenergy metabolism
dc.subjectfibromyalgia
dc.subjectinflammation
dc.subjectmitochondrion
dc.subjectpain
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectperipheral nerve
dc.subjectphysiology
dc.subjectskin
dc.subjectAdult
dc.subjectBiopsy
dc.subjectEnergy Metabolism
dc.subjectFemale
dc.subjectFibromyalgia
dc.subjectHumans
dc.subjectInflammation
dc.subjectMiddle Aged
dc.subjectMitochondria
dc.subjectOxidative Stress
dc.subjectPain
dc.subjectPeripheral Nerves
dc.subjectSkin
dc.titleOxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia
dc.typeArticle


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