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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

dc.contributor.authorSolé-Magdalena A.
dc.contributor.authorMartínez-Alonso M.
dc.contributor.authorCoronado C.A.
dc.contributor.authorJunquera L.M.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:28:37Z
dc.date.available2020-09-02T22:28:37Z
dc.date.issued2018
dc.identifier10.1016/j.aanat.2017.09.006
dc.identifier.citation215, , 20-29
dc.identifier.issn09409602
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6273
dc.descriptionOdontoblasts are the dental pulp cells responsible for the formation of dentin. In addition, accumulating data strongly suggest that they can also function as sensory cells that mediate the early steps of mechanical, thermic, and chemical dental sensitivity. This assumption is based on the expression of different families of ion channels involved in various modalities of sensitivity and the release of putative neurotransmitters in response to odontoblast stimulation which are able to act on pulp sensory nerve fibers. This review updates the current knowledge on the expression of transient-potential receptor ion channels and acid-sensing ion channels in odontoblasts, nerve fibers innervating them and trigeminal sensory neurons, as well as in pulp cells. Moreover, the innervation of the odontoblasts and the interrelationship been odontoblasts and nerve fibers mediated by neurotransmitters was also revisited. These data might provide the basis for novel therapeutic approaches for the treatment of dentin sensibility and/or dental pain. © 2017
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectAcid-sensing ion channels
dc.subjectATP
dc.subjectATP receptors
dc.subjectDentin sensitivity
dc.subjectOdontoblasts
dc.subjectTransient-receptor potential ion channels
dc.subjectacid sensing ion channel
dc.subjectadenosine triphosphate
dc.subjection channel
dc.subjectneurotransmitter
dc.subjecttransient receptor potential channel
dc.subjecttransient receptor potential channel
dc.subjectvanilloid receptor
dc.subjectcell stimulation
dc.subjectchemosensor
dc.subjectcilium
dc.subjectdentin sensitivity
dc.subjecthuman
dc.subjectinnervation
dc.subjectmechanosensor
dc.subjectmolecular biology
dc.subjectnerve fiber
dc.subjectnonhuman
dc.subjectodontoblast
dc.subjectprotein expression
dc.subjectprotein family
dc.subjectReview
dc.subjectsensory nerve
dc.subjectsensory nerve cell
dc.subjectsignal transduction
dc.subjecttooth pain
dc.subjecttooth pulp
dc.subjecttrigeminal nucleus
dc.subjectdentin sensitivity
dc.subjectinnervation
dc.subjectodontoblast
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectsensory nerve cell
dc.subjectDental Pulp
dc.subjectDentin Sensitivity
dc.subjectHumans
dc.subjectOdontoblasts
dc.subjectSensory Receptor Cells
dc.subjectTransient Receptor Potential Channels
dc.subjectTRPV Cation Channels
dc.titleMolecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels
dc.typeReview


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