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Cellular effectors of the inflammatory response in chronic obstructive pulmonary disease (COPD) [Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica]

dc.contributor.authorSilva O. R.
dc.contributor.authorMontes J.F.
dc.contributor.authorGarcía-Valero J.
dc.contributor.authorOlloquequi J.
dc.date.accessioned2020-09-02T22:28:17Z
dc.date.available2020-09-02T22:28:17Z
dc.date.issued2015
dc.identifier10.4067/s0034-98872015000900009
dc.identifier.citation143, 9, 1162-1171
dc.identifier.issn00349887
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6265
dc.descriptionApproximately 3 million people in the world die every year as a consequence of COPD, which is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes pathological changes leading to a narrowing of small airways and destruction of lung parenchyma, also known as emphysema. Classically, these changes were associated to macrophages and neutrophils, although T CD8+ lymphocytes were latter added to the equation to explain the origin of emphysematous lesions. However, in recent years, multiple evidences have arisen indicating that inflammatory response in COPD is much more complex. These findings point to a key role for mast cells, dendritic cells, T CD4+ and B cells. The aim of this article is to review such evidence and report what is known so far about those cells involved in the inflammatory response in COPD. © 2015, Sociedad Medica de Santiago. All Rights Reserved.
dc.language.isoes
dc.publisherSociedad Medica de Santiago
dc.subjectChronic obstructive
dc.subjectEmphysema
dc.subjectImmunity
dc.subjectInflammation
dc.subjectLeukocytes
dc.subjectPulmonary disease
dc.subjectB lymphocyte
dc.subjectCD4+ T lymphocyte
dc.subjectCD8+ T lymphocyte
dc.subjectchronic obstructive lung disease
dc.subjectdendritic cell
dc.subjecthuman
dc.subjectinflammation
dc.subjectlung alveolus macrophage
dc.subjectmast cell
dc.subjectneutrophil
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectB-Lymphocytes
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectDendritic Cells
dc.subjectHumans
dc.subjectInflammation
dc.subjectMacrophages, Alveolar
dc.subjectMast Cells
dc.subjectNeutrophils
dc.subjectPulmonary Disease, Chronic Obstructive
dc.titleCellular effectors of the inflammatory response in chronic obstructive pulmonary disease (COPD) [Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica]
dc.typeArticle


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