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Beneficial effects of n-hexane bark extract of Onosma echioides L. on diabetic peripheral neuropathy

dc.contributor.authorShoaib A.
dc.contributor.authorBadruddeen
dc.contributor.authorDixit R.K.
dc.contributor.authorGanash M.
dc.contributor.authorBarreto G.
dc.contributor.authorAshraf G.M.
dc.contributor.authorSiddiqui H.H.
dc.date.accessioned2020-09-02T22:28:15Z
dc.date.available2020-09-02T22:28:15Z
dc.date.issued2019
dc.identifier10.1002/jcb.28912
dc.identifier.citation120, 10, 16524-16532
dc.identifier.issn07302312
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6252
dc.descriptionOnosma echioides Linn (Boraginaceae) is the most frequently used curative herb widely used for kidney obstruction, sciatic pain, and gout. The present study was designed to investigate the therapeutic effects of n-hexane bark extract of O. echioides (OE) L. root in vivo against Streptozotocin-induced diabetic neuropathy in SD rats. For in vivo activity, the experiment was categorized into five different groups (n = 5). Group-I was considered as nondiabetic/normal control (NC) treated with 0.5% carboxymethyl cellulose (CMC), Group II as diabetic control, Group-III, IV, and V served as diabetic treated with OE 50, OE 100, and pregabalin at a dose of 50, 100, and 10 mg/kg body weight, orally, respectively. Body weight, blood glucose, oral glucose tolerance test, behavioral studies (motor coordination test, thermal hyperalgesia, cold allodynia, locomotor activity, oxidative biomarkers (thio barbituric acid reactive substances [TBARS], superoxide dismutase [SOD], glutathione [GSH], and catalase), and histopathology of the sciatic nerve were performed. Treatment with OE showed a dose-dependent increase in neuroprotective activity by improving the myelination and decreasing the axonal swelling of nerve fibers. The verdicts of behavioral activities showed a remarkable effect on animals after the treatment of extract and standard drug pregabalin. In conclusion, our findings supported the traditional application of OE and explored its importance in the management of diabetic neuropathy. Additional clinical experiments may provide novel therapeutic drugs for diabetes and its complications. © 2019 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectbehavioral effect
dc.subjectdiabetic neuropathy
dc.subjecthistopathology
dc.subjectOnosma echioides
dc.subjectoxidative biomarkers
dc.subjectcarboxymethylcellulose
dc.subjectcatalase
dc.subjectglucose
dc.subjectglutathione
dc.subjecthexane
dc.subjectneuroprotective agent
dc.subjectOnosma echioides linn extract
dc.subjectplant extract
dc.subjectpregabalin
dc.subjectstreptozocin
dc.subjectsuperoxide dismutase
dc.subjectthiobarbituric acid reactive substance
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbark
dc.subjectbody weight
dc.subjectBoraginaceae
dc.subjectcold allodynia
dc.subjectcontrolled study
dc.subjectdrug dose increase
dc.subjectdrug dose reduction
dc.subjectglucose blood level
dc.subjectin vivo study
dc.subjectmale
dc.subjectmotor coordination
dc.subjectmotor function test
dc.subjectmyelination
dc.subjectnerve fiber
dc.subjectnerve fiber degeneration
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectOnosma echioides linn
dc.subjectoral glucose tolerance test
dc.subjectplant root
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectrat
dc.subjectsciatic nerve
dc.subjectSprague Dawley rat
dc.subjectstreptozotocin-induced diabetic neuropathy
dc.subjecttherapy effect
dc.subjectthermal hyperalgesia
dc.subjecttissue section
dc.titleBeneficial effects of n-hexane bark extract of Onosma echioides L. on diabetic peripheral neuropathy
dc.typeArticle


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