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Mitochondrial permeability transition pore as a suitable target for neuroprotective agents against alzheimer’s disease

dc.contributor.authorShevtsova E.F.
dc.contributor.authorVinogradova D.V.
dc.contributor.authorNeganova M.E.
dc.contributor.authorAvila-Rodriguez M.
dc.contributor.authorAshraf G.M.
dc.contributor.authorBarreto G.E.
dc.contributor.authorBachurin S.O.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:28:14Z
dc.date.available2020-09-02T22:28:14Z
dc.date.issued2017
dc.identifier10.2174/1871527316666170424114444
dc.identifier.citation16, 6, 677-685
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6251
dc.descriptionBackground: A considerable amount of data suggests the age-related impairments of mitochondrial functions in the development of sporadic forms of neurodegenerative pathologies. Mitochondria and the phenomenon of mitochondrial permeability transition (MPT), which marks the point of no return in cell death cascades, have special value in this regard. It is important that the vulnerability to MPT-inducing factors is increased with aging. Simultaneously, a decrease in the calcium retention capacity of mitochondria is developed, which leads to the disturbance of the functional activity of neurons. Method: The systematic investigations and web content related to the importance of MPT as the target for the search of neuroprotective and cognitive enhancing drugs, especially with multitargeted action, are reviewed. Results: Here, we have highlighted some experimental data that determines the importance of mitochondria for the search of neuroprotective drugs, and drugs with multitargeted action. We have also discussed a number of new compounds with similar properties. Being MPT inhibitors/modulators, virtually all the compounds described in this review have the ability to exhibit a neuroprotective effect, interact with some other targets, providing coupled beneficial therapeutic effects such as cognitive stimulation, anti-seizure, and antidepressant actions. Conclusion: Inhibitors of MPT, which increases calcium retention capacity of mitochondria, are considered as promising neuroprotective drugs able not only to halt the neurodegenerative cascade, but also to increase the functional activity of neurons. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAlzheimer's disease
dc.subjectMitochondria
dc.subjectMitochondrial dysfunction
dc.subjectMultitarget benefits
dc.subjectNeurodegenerative diseases
dc.subjectNeuroprotective
dc.subjectalisporivir
dc.subjectamide
dc.subjectamyloid beta protein
dc.subjectazasteroid
dc.subjectcyclosporin A [4 n methylisoleucine]
dc.subjectdimebon
dc.subjectmelatonin
dc.subjectmitochondrial permeability transition pore
dc.subjectn acetylserotonin
dc.subjectneuroprotective agent
dc.subjectpilocarpine
dc.subjectsecurinine
dc.subjecttryptamine
dc.subjectcarrier protein
dc.subjectmitochondrial permeability transition pore
dc.subjectneuroprotective agent
dc.subjectAlzheimer disease
dc.subjectantidepressant activity
dc.subjectArticle
dc.subjectcalcium transport
dc.subjectcell function
dc.subjectcell organelle
dc.subjectcognition
dc.subjecthuman
dc.subjectimmunosuppressive treatment
dc.subjectmetabolic balance
dc.subjectmitochondrial membrane potential
dc.subjectmolecular interaction
dc.subjectnerve degeneration
dc.subjectnerve stimulation
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectprotein targeting
dc.subjectseizure
dc.subjectsystematic review
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectdrug effect
dc.subjectmitochondrion
dc.subjectphysiology
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectHumans
dc.subjectMitochondria
dc.subjectMitochondrial Membrane Transport Proteins
dc.subjectNeuroprotective Agents
dc.titleMitochondrial permeability transition pore as a suitable target for neuroprotective agents against alzheimer’s disease
dc.typeArticle


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