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Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis

dc.contributor.authorSerrano-Pertierra E.
dc.contributor.authorBlanco-Gelaz M.A.
dc.contributor.authorOliva-Nacarino P.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorVillafani J.
dc.contributor.authorLópez-Larrea C.
dc.contributor.authorCernuda-Morollón E.
dc.date.accessioned2020-09-02T22:28:12Z
dc.date.available2020-09-02T22:28:12Z
dc.date.issued2015
dc.identifier10.1016/j.jneuroim.2015.03.007
dc.identifier.citation282, , 39-44
dc.identifier.issn01655728
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6240
dc.descriptionMultiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by leukocyte infiltration into the central nervous system (CNS). Migration of lymphocyte subpopulations towards CXCL12 was analyzed coupled to six-color flow cytometry in untreated patients in the remitting phase, during relapse, in patients with clinically isolated syndrome (CIS), and in healthy volunteers. Significantly higher migration rates of natural killer cells (CD45+CD3-CD16/56. +) were observed in patients in remission and CIS patients than in patients during relapse and in controls. Moreover, the frequency of CD3-CD16/56+CXCR4. + cells is higher in patients in remission and in CIS patients, but not during relapse. © 2015 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectChemotaxis
dc.subjectCXCL12
dc.subjectCXCR4
dc.subjectMultiple sclerosis
dc.subjectNK
dc.subjectCD16 antigen
dc.subjectCD3 antigen
dc.subjectCD45 antigen
dc.subjectCD56 antigen
dc.subjectchemokine receptor CXCR4
dc.subjectstromal cell derived factor 1
dc.subjectchemokine receptor CXCR4
dc.subjectCXCR4 protein, human
dc.subjectcytokine
dc.subjectstromal cell derived factor 1
dc.subjectadult
dc.subjectArticle
dc.subjectcell infiltration
dc.subjectcentral nervous system
dc.subjectchemotaxis
dc.subjectcontrolled study
dc.subjectdegenerative disease
dc.subjectdemyelinating disease
dc.subjectfemale
dc.subjectflow cytometry
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectinflammatory disease
dc.subjectleukocyte
dc.subjectlymphocyte migration
dc.subjectmale
dc.subjectmultiple sclerosis
dc.subjectnatural killer cell
dc.subjectpriority journal
dc.subjectrelapse
dc.subjectremission
dc.subjectanalysis of variance
dc.subjectdrug effects
dc.subjectlymphocyte subpopulation
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmultiple sclerosis
dc.subjectnatural killer cell
dc.subjectneutrophil chemotaxis
dc.subjectpathology
dc.subjectphysiology
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectCentral Nervous System
dc.subjectChemokine CXCL12
dc.subjectChemotaxis, Leukocyte
dc.subjectCytokines
dc.subjectFemale
dc.subjectFlow Cytometry
dc.subjectHumans
dc.subjectKiller Cells, Natural
dc.subjectLymphocyte Subsets
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultiple Sclerosis
dc.subjectReceptors, CXCR4
dc.subjectYoung Adult
dc.titleIncreased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis
dc.typeArticle


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