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Host-guest interactions of non-steroidal anti-inflammatory drugs on the functionalized dendronized polymeric nanocomposite, Poly(N-tris[((cyano-ethoxy)methyl] methylacrylamide).

dc.contributor.authorSchmidt M.
dc.contributor.authorSaavedra M.
dc.contributor.authorAlegría L.
dc.contributor.authorAlvarado N.
dc.contributor.authorFuentes I.
dc.contributor.authorMenares P.
dc.contributor.authorKortaberría G.
dc.contributor.authorGargallo L.
dc.contributor.authorSaldías C.
dc.contributor.authorLeiva A.
dc.contributor.authorRadić D.
dc.date.accessioned2020-09-02T22:28:08Z
dc.date.available2020-09-02T22:28:08Z
dc.date.issued2018
dc.identifier10.1080/10601325.2018.1426389
dc.identifier.citation55, 3, 296-309
dc.identifier.issn10601325
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6217
dc.descriptionThe use of dendronized polymers (DP), such as Poly(N-tris[((cyano-ethoxy)methyl]methylacrylamide) (PATCN), as carriers models of different non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (IBU), Ketoprofen (KTP), and Naproxen (NPX), is reported. DSC and TGA measurements demonstrate strong interactions between dendronized polymeric nanocomposites and these drugs. FT-IR, UV-Vis, and AFM measurements confirm that the interactions in the blend give rise to a compatible new material in only one phase. Using the Fukui Theory (FT), the interaction appears to take place through the main amide and its neighborhood. Thus, the drugs' and polymer's functional groups contribute to the strength of the interaction. The functional groups and the sizes of the drugs are the driving force for the interaction with the DP. Finally, MD calculations are carried out through DFT methods to investigate the behavior of the dendronized polymer, showing that different chain behaviors depend on the placement of the lateral chains. © 2018 Taylor & Francis Group, LLC.
dc.language.isoen
dc.publisherTaylor and Francis Inc.
dc.subjectCavities
dc.subjectFukui
dc.subjectIbuprofen (IBU)
dc.subjectKetoprofen (KTP)
dc.subjectNaproxen (NPX)
dc.subjectPoly(N-tris[((cyano-ethoxy)methyl]methylacrylamide) (PATCN)
dc.subjectPolymer blends
dc.subjectChains
dc.subjectNanocomposites
dc.subjectPolymer blends
dc.subjectCavities
dc.subjectFukui
dc.subjectIbuprofen (IBU)
dc.subjectKetoprofen
dc.subjectNaproxens
dc.subjectPoly(N-tris[((cyano-ethoxy)methyl]methylacrylamide) (PATCN)
dc.subjectDrug interactions
dc.titleHost-guest interactions of non-steroidal anti-inflammatory drugs on the functionalized dendronized polymeric nanocomposite, Poly(N-tris[((cyano-ethoxy)methyl] methylacrylamide).
dc.typeArticle


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