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Psoriasis vulgaris with or without arthritis and independent of disease severity or duration is a risk factor for hypercholesterolemia

dc.contributor.authorSantos-Juanes J.
dc.contributor.authorCoto-Segura P.
dc.contributor.authorFernández-Vega I.
dc.contributor.authorArmesto S.
dc.contributor.authorMartínez-Camblor P.
dc.date.accessioned2020-09-02T22:28:05Z
dc.date.available2020-09-02T22:28:05Z
dc.date.issued2015
dc.identifier10.1159/000369884
dc.identifier.citation230, 2, 170-176
dc.identifier.issn10188665
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6194
dc.descriptionBackground: Psoriasis (Ps) has been associated with an increased incidence of cardiovascular disease. Interesting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease. Objective: This study aimed to investigate the association between Ps and multiple measurements of DL, which include levels of triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol (TCh). We also studied the relationship between DL and disease duration. Methods: A prospective hospital-based study was conducted. A total of 661 Caucasian patients with chronic plaque Ps and 661 sex- and age-matched controls were enrolled. Results: Multivariate analysis showed that in psoriatic patients the odds ratio (OR) of TCh >200 mg/dl was 1.406 (95% confidence interval 1.115-1.173), the OR of LDL cholesterol >130 mg/dl was 1.375 (95% confidence interval 1.088-1.738), the OR of HDL cholesterol <40 mg/dl was 0.881 (95% confidence interval 0.599-1.297), and the OR of TGs >150 mg/dl was 1.041 (95% confidence interval 0.783-1.385). We did not find a relationship between lipid levels and disease duration. Conclusion: Based on our population Ps is associated with alterations in TCh and LDL cholesterol, but not in TGs and HDL cholesterol, when ATP III panel levels are used. These alterations are not related to disease duration. © 2015 S. Karger AG, Basel.
dc.language.isoen
dc.publisherS. Karger AG
dc.subjectLipids
dc.subjectPsoriasis
dc.subjectcholesterol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectcholesterol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectarthritis
dc.subjectArticle
dc.subjectCaucasian
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectdyslipidemia
dc.subjectfemale
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjectlipoprotein blood level
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmeasurement
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectpsoriasis vulgaris
dc.subjectrisk
dc.subjectrisk factor
dc.subjecttriacylglycerol blood level
dc.subjectadult
dc.subjectaged
dc.subjectblood
dc.subjectcase control study
dc.subjecthypercholesterolemia
dc.subjectmiddle aged
dc.subjectpsoriasis
dc.subjectpsoriatic arthritis
dc.subjectseverity of illness index
dc.subjecttime
dc.subjectAdult
dc.subjectAged
dc.subjectArthritis, Psoriatic
dc.subjectCase-Control Studies
dc.subjectCholesterol
dc.subjectCholesterol, HDL
dc.subjectCholesterol, LDL
dc.subjectFemale
dc.subjectHumans
dc.subjectHypercholesterolemia
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectPsoriasis
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectTime Factors
dc.subjectTriglycerides
dc.titlePsoriasis vulgaris with or without arthritis and independent of disease severity or duration is a risk factor for hypercholesterolemia
dc.typeArticle


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