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Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin

dc.contributor.authorSalinas-Muñoz M.
dc.contributor.authorGarrido-Flores M.
dc.contributor.authorBaeza M.
dc.contributor.authorHuamán-Chipana P.
dc.contributor.authorGarcía-Sesnich J.
dc.contributor.authorBologna R.
dc.contributor.authorVernal R.
dc.contributor.authorHernández M.
dc.date.accessioned2020-09-02T22:27:41Z
dc.date.available2020-09-02T22:27:41Z
dc.date.issued2017
dc.identifier10.1007/s00784-017-2062-x
dc.identifier.citation21, 8, 2613-2618
dc.identifier.issn14326981
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6160
dc.descriptionObjectives: The aim of this study is to assess the levels and diagnostic accuracy of a set of bone resorption biomarkers, including TRAP-5, RANKL, and OPG in symptomatic and asymptomatic apical lesions and controls. Materials and methods: Apical tissues from symptomatic and asymptomatic apical periodontitis patients and periodontal ligaments from healthy teeth extracted for orthodontic reasons were processed for tissue homogenization and the levels of TRAP-5, RANKL, and OPG were determined by multiplex assay. Marker levels were analyzed by Kruskal Wallis test, and diagnostic accuracy was analyzed with ROC curves. Results: Higher levels of RANKL, OPG, and RANKL/OPG ratio were determined in both types of apical lesions compared to healthy periodontal ligament, whereas higher TRAP-5 levels were found only in symptomatic apical lesions (p < 0.05). OPG, RANKL, and RANKL/OPG ratio showed diagnostic potential to identify apical lesions versus healthy controls (AUC = 0.69, p < 0.05); while TRAP-5 showed a potential to discriminate symptomatic versus asymptomatic apical periodontitis (AUC = 0.71, p < 0.05) and healthy controls (AUC = 0.83, p < 0.05). Conclusions: Apical lesions showed higher RANKL and OPG levels than healthy tissues. TRAP-5 levels were the highest in symptomatic apical lesions, suggesting that these represent a progressive state, and showed diagnostic potential. Clinical relevance: Clinically symptomatic apical periodontitis might represent biologically progressive apical lesions based on TRAP5 levels. TRAP5 has diagnostic potential to identify these lesions, representing a candidate prognostic biomarker. © 2017, The Author(s).
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectAsymptomatic periapical periodontitis
dc.subjectBiomarkers
dc.subjectBone resorption
dc.subjectOPG
dc.subjectRANKL
dc.subjectSymptomatic
dc.subjectTRAP
dc.subjectacid phosphatase tartrate resistant isoenzyme
dc.subjectACP5 protein, human
dc.subjectbiological marker
dc.subjectosteoclast differentiation factor
dc.subjectosteoprotegerin
dc.subjectadolescent
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectosteolysis
dc.subjectpathology
dc.subjectperiodontal ligament
dc.subjecttooth periapical disease
dc.subjectAdolescent
dc.subjectBiomarkers
dc.subjectBone Resorption
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOsteoprotegerin
dc.subjectPeriapical Periodontitis
dc.subjectPeriodontal Ligament
dc.subjectRANK Ligand
dc.subjectTartrate-Resistant Acid Phosphatase
dc.titleBone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin
dc.typeArticle


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