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Role of exercise in the mechanisms ameliorating hepatic steatosis in non-alcoholic fatty liver disease

dc.contributor.authorRussell-Guzmán J.A.
dc.contributor.authorKarachon L.
dc.contributor.authorGacitúa T.A.
dc.contributor.authorFreundlich A.
dc.contributor.authorPoblete-Aro C.E.
dc.contributor.authorRodrigo R.
dc.date.accessioned2020-09-02T22:27:35Z
dc.date.available2020-09-02T22:27:35Z
dc.date.issued2018
dc.identifier10.1007/s11332-018-0459-9
dc.identifier.citation14, 3, 463-473
dc.identifier.issn18247490
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6125
dc.descriptionHepatic steatosis is an abnormal lipid accumulation within hepatocytes, generally present in non-alcoholic fatty liver disease (NAFLD) patients, a starting-point pathology currently associated with other clinical manifestations such as metabolic syndrome, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Hepatic steatosis in NAFLD may be induced by mechanisms such as insulin resistance, increased fatty acid uptake, a higher de novo lipogenesis from glucose or acetate, lower fatty acids oxidation and a decrease in fatty acid mobilization from liver. Among different therapeutic strategies appropriate for these patients, exercise has shown to be effective in reversing hepatic steatosis. However, the specific mechanisms involved in this response remain unclear. Therefore, the aim of this review is (1) to describe the mechanisms whereby exercise reverts hepatic steatosis, and (2) review the clinical outcomes of different exercise modalities in NAFLD parameters. Therefore, this knowledge may provide the basis suggesting potential clinical benefits of exercise as an adjunct therapy for patients with NAFLD and associated metabolic diseases. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.
dc.language.isoen
dc.publisherSpringer-Verlag Italia s.r.l.
dc.subjectExercise
dc.subjectHepatic steatosis
dc.subjectNon-alcoholic fatty liver disease
dc.titleRole of exercise in the mechanisms ameliorating hepatic steatosis in non-alcoholic fatty liver disease
dc.typeReview


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