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Goldfish hippocampal pallium is essential to associate temporally discontiguous events

dc.contributor.authorRodríguez-Expósito B.
dc.contributor.authorGómez A.
dc.contributor.authorMartín-Monzón I.
dc.contributor.authorReiriz M.
dc.contributor.authorRodríguez F.
dc.contributor.authorSalas C.
dc.date.accessioned2020-09-02T22:27:06Z
dc.date.available2020-09-02T22:27:06Z
dc.date.issued2017
dc.identifier10.1016/j.nlm.2017.01.002
dc.identifier.citation139, , 128-134
dc.identifier.issn10747427
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6056
dc.descriptionThere is general agreement that the hippocampus of vertebrates, from fish to mammals, is involved in map-like spatial memory. However, in mammals the role of the hippocampus goes beyond the spatial domain as it is also involved in binding the temporally separate events that compose episodic memories. In this regard, the hippocampus of mammals is essential for trace classical conditioning, in which a stimulus-free time gap separates the conditioned stimulus (CS) and the unconditioned stimulus (US), but not for delay conditioning, in which both stimuli coincide in time. Although the involvement of the hippocampus in encoding relational memories based on a temporal frame-work has been extensively studied in mammals, there is scarce evidence about the possible contribution of the hippocampus of non-mammalian vertebrates to the temporal, non-spatial dimension of relational memories. The present work was aimed to determine if the ventral part of the lateral division of the area dorsalis telencephali (Dlv) of goldfish, proposed as homologous to the hippocampus of mammals, is also involved in trace classical conditioning. With this purpose, goldfish with lesions in Dlv, complete telencephalon ablation and sham operation, were trained in delay and trace heart rate classical conditioning. Dlv lesions severely impaired the acquisition of the conditioned response when a stimulus-free time gap was elapsed between the CS and the US (trace conditioning), but not when both stimuli overlapped in time (delay conditioning), revealing that this region, like the hippocampus of mammals, is essential to form the temporal associative memories required by trace conditioning. Present data suggest that the presence of a hippocampal pallium involved in relational, episodic-like memory that preserves both the spatial and the temporal dimensions of past events, could be a primitive feature of the vertebrate brain that has been conserved through evolution. © 2017 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectDelay versus trace classical conditioning
dc.subjectEpisodic-like memory
dc.subjectHippocampal pallium
dc.subjectTeleost fish telencephalic pallium
dc.subjectVertebrate brain evolution
dc.subjectassociative memory
dc.subjectbrain cortex
dc.subjectconditioned reflex
dc.subjectgoldfish
dc.subjectheart rate
dc.subjecthippocampus
dc.subjectmammal
dc.subjectnonhuman
dc.subjectsham procedure
dc.subjectstimulus
dc.subjectanimal
dc.subjectassociative learning
dc.subjectconditioned reflex
dc.subjectglobus pallidus
dc.subjectgoldfish
dc.subjecthippocampus
dc.subjectmemory
dc.subjectphysiology
dc.subjecttime factor
dc.subjectAnimals
dc.subjectAssociation Learning
dc.subjectConditioning, Classical
dc.subjectGlobus Pallidus
dc.subjectGoldfish
dc.subjectHippocampus
dc.subjectMemory
dc.subjectTime Factors
dc.titleGoldfish hippocampal pallium is essential to associate temporally discontiguous events
dc.typeArticle


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