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Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action

dc.contributor.authorRobles-Kelly C.
dc.contributor.authorRubio J.
dc.contributor.authorThomas M.
dc.contributor.authorSedán C.
dc.contributor.authorMartinez R.
dc.contributor.authorOlea A.F.
dc.contributor.authorCarrasco H.
dc.contributor.authorTaborga L.
dc.contributor.authorSilva-Moreno E.
dc.date.accessioned2020-09-02T22:27:03Z
dc.date.available2020-09-02T22:27:03Z
dc.date.issued2017
dc.identifier10.1016/j.pestbp.2016.11.006
dc.identifier.citation141, , 50-56
dc.identifier.issn00483575
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6034
dc.descriptionThe aim of this study was to determine the antifungal activity of Drimenol (1) and its synthetic derivatives, nordrimenone (2), drimenyl acetate (3), and drimenyl-epoxy-acetate (4), and to establish a possible mechanism of action for drimenol. For that, the effect of each compound on mycelial growth of Botrytis cinerea was assessed. Our results showed that compounds 1, 2, 3 and 4 are able to affect Botrytis cinerea growth with EC50 values of 80, 92, 80 and 314 ppm, respectively. These values suggest that the activity of these compounds is mainly determined by presence of the double bond between carbons 7 and 8 of the drimane ring. In addition, germination of B. cinerea in presence of 40 and 80 ppm of drimenol is reduced almost to a half of the control value. Finally, in order to elucidate a possible mechanism by which drimenol is affecting B. cinerea, the determination of membrane integrity, reactive oxygen species production and gene expression studies of specific genes were performed. © 2016 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectAntifungal activity
dc.subjectBotrytis cinerea
dc.subjectDrimenol
dc.subjectantifungal agent
dc.subjectdrimenol
dc.subjectfungicide
dc.subjectreactive oxygen metabolite
dc.subjectterpene
dc.subjectBotrytis
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectfungus spore
dc.subjectmetabolism
dc.subjectAntifungal Agents
dc.subjectBotrytis
dc.subjectFungicides, Industrial
dc.subjectReactive Oxygen Species
dc.subjectSpores, Fungal
dc.subjectTerpenes
dc.titleEffect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action
dc.typeArticle


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