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Gold nanoparticles: A plausible tool to combat neurological bacterial infections in humans

dc.contributor.authorRizvi S.M.D.
dc.contributor.authorHussain T.
dc.contributor.authorAhmed A.B.F.
dc.contributor.authorAlshammari T.M.
dc.contributor.authorMoin A.
dc.contributor.authorAhmed M.Q.
dc.contributor.authorBarreto G.E.
dc.contributor.authorKamal M.A.
dc.contributor.authorAshraf G.M.
dc.date.accessioned2020-09-02T22:27:02Z
dc.date.available2020-09-02T22:27:02Z
dc.date.issued2018
dc.identifier10.1016/j.biopha.2018.07.130
dc.identifier.citation107, , 7-18
dc.identifier.issn07533322
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6027
dc.descriptionManagement of bacterial infections of central nervous system is a major challenge for the scientists all over the world. Despite the development of various potential drugs, the issue of central nervous system infections persists in the society. The main constraint is the delivery of drugs across the blood brain barrier and only a few drugs after meeting the stringent criteria could cross the blood brain barrier. On the other hand, certain bacterial pathogens could easily enter the brain by using several factors and mechanisms by crossing the blood brain barriers. Interestingly, in the recent past, gold nanoparticles have shown immense potential to overcome the issues associated with the treatment of central nervous system infections, especially due to their inherent ability to cross the blood brain barrier. Initially, the present review summarized the recent updates on the pathogenesis and factors involved in neurological bacterial infections, including the mechanism used by bacterial pathogens to cross the blood brain barriers. Thereafter, the emphasis of the review was on providing current information on gold nanoparticles pertinent to their applicability for the treatment of neurological infections. After discussing the background of neurological bacterial infections, the characteristic features, antibacterial properties, mechanisms of antibacterial action and ability to cross the blood brain barrier of gold nanoparticles have been summarized. Some of the features of gold nanoparticles that make them an ideal candidate for brain delivery are biocompatibity, stability, ability to get synthesized in different sizes with facile methods, surface affinity towards various functional groups, spontaneous crossing of blood brain barrier without applying any external field and most importantly, easy non-invasive tracing by CT imaging. The current updates on the development of gold nanoparticles based therapeutic strategies for the prevention and treatment of central nervous system infections have been discussed in the present study. However, further investigation would be required to translate these preclinical outcomes into clinical applications. Nevertheless, we could safely state that the information gathered and discussed in the present review would benefit the scientists working in the field of neuro-nanotechnology. © 2018 Elsevier Masson SAS
dc.language.isoen
dc.publisherElsevier Masson SAS
dc.subjectBacterial meningitis
dc.subjectBlood brain barrier
dc.subjectDrug delivery
dc.subjectGold nanoparticles
dc.subjectNanotechnology
dc.subjectNeurological bacterial infections
dc.subjectfunctional group
dc.subjectgold nanoparticle
dc.subjectantiinfective agent
dc.subjectgold
dc.subjectmetal nanoparticle
dc.subjectantibacterial activity
dc.subjectbacterial translocation
dc.subjectblood brain barrier
dc.subjectbrain infection
dc.subjectcentral nervous system infection
dc.subjectcomputer assisted tomography
dc.subjecthuman
dc.subjectnanotechnology
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectReview
dc.subjectsurface property
dc.subjectanimal
dc.subjectbacterial infection
dc.subjectcentral nervous system
dc.subjectchemistry
dc.subjectmicrobiology
dc.subjectpathology
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectBacterial Infections
dc.subjectBlood-Brain Barrier
dc.subjectCentral Nervous System
dc.subjectGold
dc.subjectHumans
dc.subjectMetal Nanoparticles
dc.titleGold nanoparticles: A plausible tool to combat neurological bacterial infections in humans
dc.typeReview


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