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Relationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients

dc.contributor.authorRiesco N.
dc.contributor.authorCernuda-Morollón E.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorPérez-Alvarez A.I.
dc.contributor.authorVerano L.
dc.contributor.authorGarcía-Cabo C.
dc.contributor.authorSerrano-Pertierra E.
dc.contributor.authorPascual J.
dc.date.accessioned2020-09-02T22:27:00Z
dc.date.available2020-09-02T22:27:00Z
dc.date.issued2017
dc.identifier10.1177/0333102416653232
dc.identifier.citation37, 9, 823-827
dc.identifier.issn03331024
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6017
dc.descriptionBackground Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine chronification. Objective The objective of this article is to correlate the presence of CAPS with serum levels of vasoactive intestinal peptides (VIP) and calcitonin gene-related peptide (CGRP). Patients and methods Patients with chronic migraine (CM) were asked about the presence - during migraine attacks - of five CAPS, which were scored from 0 to 10 by using a quantitative scale. Serum VIP and CGRP levels were determined by ELISA. Results We interviewed 87 CM patients (82 females; mean age 44.7 ± 10.6 years). Seventeen had no CAPS, while 70 reported at least one CAPS. VIP levels ranged from 20.8 to 668.2 pg/ml (mean 154.5 ± 123.2). There was a significant positive correlation between scores in the CAPS scale and VIP levels (Spearman correlation coefficient = 0.227; p = 0.035). VIP levels were significantly higher in CM patients by at least one point in the scale vs those with 0 points (p = 0.002). Analysing symptoms individually, VIP levels were numerically higher in those patients with symptoms, though they were significantly higher only in those patients with lacrimation vs those without it (p = 0.013). There was no significant correlation between CGRP levels and the score in the CAPS scale. Conclusions Serum VIP, but not CGRP, levels seem to reflect the rate of activation of the parasympathetic arm of the TVS in migraine. © 2016 International Headache Society.
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.subjectCGRP
dc.subjectChronic migraine
dc.subjectcranial autonomic parasympathetic symptoms
dc.subjectVIP
dc.subjectcalcitonin gene related peptide
dc.subjectvasoactive intestinal polypeptide
dc.subjectCALCA protein, human
dc.subjectcalcitonin gene related peptide
dc.subjectvasoactive intestinal polypeptide
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectconjunctiva disease
dc.subjectcorrelation analysis
dc.subjectcranial autonomic parasympathetic symptom
dc.subjectear disease
dc.subjectenzyme linked immunosorbent assay
dc.subjecteyelid edema
dc.subjectfemale
dc.subjecthuman
dc.subjectinterview
dc.subjectlacrimation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnose obstruction
dc.subjectparasympathetic innervation
dc.subjectquantitative analysis
dc.subjectrhinorrhea
dc.subjectsymptom
dc.subjecttransformed migraine
dc.subjectyoung adult
dc.subjectautonomic neuropathy
dc.subjectblood
dc.subjectcomplication
dc.subjectmigraine
dc.subjectAdult
dc.subjectAged
dc.subjectAutonomic Nervous System Diseases
dc.subjectCalcitonin Gene-Related Peptide
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMigraine Disorders
dc.subjectVasoactive Intestinal Peptide
dc.subjectYoung Adult
dc.titleRelationship between serum levels of VIP, but not of CGRP, and cranial autonomic parasympathetic symptoms: A study in chronic migraine patients
dc.typeArticle


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