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Brown seaweed fucoidan in cancer: Implications in metastasis and drug resistance

dc.contributor.authorReyes M.E.
dc.contributor.authorRiquelme I.
dc.contributor.authorSalvo T.
dc.contributor.authorZanella L.
dc.contributor.authorLetelier P.
dc.contributor.authorBrebi P.
dc.date.accessioned2020-09-02T22:26:58Z
dc.date.available2020-09-02T22:26:58Z
dc.date.issued2020
dc.identifier10.3390/md18050232
dc.identifier.citation18, 5, -
dc.identifier.issn16603397
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6006
dc.descriptionFucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity of fucoidans and their similarity with other molecules such as glycosaminoglycan, which enable them to participation in diverse biological processes. Furthermore, this review summarizes their influence on the development of metastasis and drug resistance, which are the main obstacles to cure cancer. Finally, this article discusses how fucoidans have been used in clinical trials to evaluate their potential synergy with other anti-cancer therapies. © 2020 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectCancer
dc.subjectEpithelial mesenchymal transition
dc.subjectFucoidan
dc.subjectMetastasis
dc.subjectNanoparticles
dc.subjectfucoidin
dc.subjectantineoplastic activity
dc.subjectbreast cancer
dc.subjectcolorectal cancer
dc.subjectdrug resistance
dc.subjectdrug structure
dc.subjecthuman
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectliver cell carcinoma
dc.subjectlung cancer
dc.subjectmalignant neoplasm
dc.subjectmetastasis
dc.subjectnon small cell lung cancer
dc.subjectnonhuman
dc.subjectpancreas cancer
dc.subjectprostate cancer
dc.subjectReview
dc.subjectseaweed
dc.subjectvitreoretinopathy
dc.titleBrown seaweed fucoidan in cancer: Implications in metastasis and drug resistance
dc.typeReview


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