Mostrar el registro sencillo del ítem

Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals

dc.contributor.authorReyes E.P.
dc.contributor.authorCerpa V.
dc.contributor.authorCorvalán L.
dc.contributor.authorRetamal M.A.
dc.date.accessioned2020-09-02T22:26:58Z
dc.date.available2020-09-02T22:26:58Z
dc.date.issued2014
dc.identifier10.3389/fncel.2014.00123
dc.identifier.citation8, MAY, -
dc.identifier.issn16625102
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6003
dc.descriptionConnexins (Cxs) and Pannexins (Panx) form hemichannels at the plasma membrane of animals. Despite their low open probability under physiological conditions, these hemichannels release signaling molecules (i.e., ATP, Glutamate, PGE2) to the extracellular space, thus subserving several important physiological processes. Oxygen and CO2 sensing are fundamental to the normal functioning of vertebrate organisms. Fluctuations in blood PO2, PCO2 and pH are sensed at the carotid bifurcations of adult mammals by glomus cells of the carotid bodies. Likewise, changes in pH and/or PCO2 of cerebrospinal fluid are sensed by central chemoreceptors, a group of specialized neurones distributed in the ventrolateral medulla (VLM), raphe nuclei, and some other brainstem areas. After many years of research, the molecular mechanisms involved in chemosensing process are not completely understood. This manuscript will review data regarding relationships between chemosensitive cells and the expression of channels formed by Cxs and Panx, with special emphasis on hemichannels. © 2014 Reyes, Cerpa, Corvalán and Retamal.
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectAstrocytes
dc.subjectCarotid body
dc.subjectConnexins
dc.subjectGap junctions
dc.subjectGlomus cells
dc.subjectHypercapnia
dc.subjectHypoxia
dc.subjectadenosine triphosphate
dc.subjectcarbon dioxide
dc.subjectgap junction protein
dc.subjectmembrane protein
dc.subjectoxygen
dc.subjectpannexin
dc.subjectunclassified drug
dc.subjectastrocyte
dc.subjectcarbon dioxide tension
dc.subjectcell communication
dc.subjectchemoreceptor
dc.subjectchemosensitivity
dc.subjectelectrophysiology
dc.subjectextracellular calcium
dc.subjectgap junction
dc.subjecthomeostasis
dc.subjecthuman
dc.subjecthypercapnia
dc.subjecthypoxia
dc.subjectnonhuman
dc.subjectoxygen tension
dc.subjectpH
dc.subjectreview
dc.titleCxs and Panx- hemichannels in peripheral and central chemosensing in mammals
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84901339927.pdf
Tamaño:
2.766Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem