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High levels of atrial natriuretic peptide and copeptin and mortality risk [Asociación de valores elevados de péptido natriurético auricular y copeptina con riesgo de mortalidad]

dc.contributor.authorRey C.
dc.contributor.authorGarcía-Cendón C.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorLópez-Herce J.
dc.contributor.authorConcha-Torre A.
dc.contributor.authorMedina A.
dc.contributor.authorVivanco-Allende A.
dc.contributor.authorMayordomo-Colunga J.
dc.date.accessioned2020-09-02T22:26:56Z
dc.date.available2020-09-02T22:26:56Z
dc.date.issued2016
dc.identifier10.1016/j.anpedi.2016.02.002
dc.identifier.citation85, 6, 284-290
dc.identifier.issn16954033
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5987
dc.descriptionObjective To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk. Methods Prospective observational study including 254 critically ill children. MR-proANP, copeptin and PCT were compared between children with high (Group A; n = 33) and low (Group B; n = 221) mortality risk, and between patients with failure of more than 1 organ (Group 1; n = 71) and less than 2 (Group 2; n = 183). Results Median (range) of MR-proANP, copeptin, and PCT levels in group A vs B were, respectively: 209.4 (30.5–1415.8) vs. 75.0 (14.6–867.2) pmol/L (P<.001); 104.4 (7.4–460.9) vs. 26.6 (0.00–613.1) pmol/L (P<.001), and 7.8 (0.3–552.0) vs. 0.3 (0.02–107.0) ng/mL (P<.001). The area under the curve (AUC) for the differentiation of group A and B was 0.764 (95% CI: 0.674-0.854) for MR-proANP; 0.735 (0.642-0.827) for copeptin, and 0.842 (0.744-0.941) for PCT, with no statistical differences. The AUCs for the differentiation of group 1 and 2 were: 0.837 (0.784-0.891) for MR-proANP, 0.735 (0.666-0.804) for copeptin, and 0.804 (0.715-0.892) for PCT, with statistical differences between MR-proANP and copeptin, P=.01. Conclusions High levels of MR-proANP, copeptin and PCT were associated with increased mortality risk scores. MR-proANP showed a higher association than copeptin with number of organs in failure. © 2015 Asociación Española de Pediatría
dc.language.isoen
dc.language.isoes
dc.publisherElsevier Doyma
dc.subjectAtrial natriuretic peptide
dc.subjectCopeptin
dc.subjectCritically ill children
dc.subjectMortality risk
dc.subjectOrgan failure
dc.subjectProcalcitonin
dc.subjectPrognosis
dc.subjectatrial natriuretic factor
dc.subjectbiological marker
dc.subjectcalcitonin
dc.subjectcopeptin
dc.subjectglycopeptide
dc.subjectadolescent
dc.subjectblood
dc.subjectchild
dc.subjectcritical illness
dc.subjectfemale
dc.subjecthuman
dc.subjectinfant
dc.subjectmale
dc.subjectmortality
dc.subjectmultiple organ failure
dc.subjectnewborn
dc.subjectpreschool child
dc.subjectprognosis
dc.subjectprospective study
dc.subjectrisk assessment
dc.subjectAdolescent
dc.subjectAtrial Natriuretic Factor
dc.subjectBiomarkers
dc.subjectCalcitonin
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCritical Illness
dc.subjectFemale
dc.subjectGlycopeptides
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectMultiple Organ Failure
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectRisk Assessment
dc.titleHigh levels of atrial natriuretic peptide and copeptin and mortality risk [Asociación de valores elevados de péptido natriurético auricular y copeptina con riesgo de mortalidad]
dc.typeArticle


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