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dc.contributor.authorRetamoso L.T.
dc.contributor.authorSilveira M.E.P.
dc.contributor.authorJr.
dc.contributor.authorLima F.D.
dc.contributor.authorBusanello G.L.
dc.contributor.authorBresciani G.
dc.contributor.authorRibeiro L.R.
dc.contributor.authorChagas P.M.
dc.contributor.authorNogueira C.W.
dc.contributor.authorBraga A.C.M.
dc.contributor.authorFurian A.F.
dc.contributor.authorOliveira M.S.
dc.contributor.authorFighera M.R.
dc.contributor.authorRoyes L.F.F.
dc.date.accessioned2020-09-02T22:26:55Z
dc.date.available2020-09-02T22:26:55Z
dc.date.issued2016
dc.identifier10.1016/j.lfs.2016.03.029
dc.identifier.citation152, , 52-59
dc.identifier.issn00243205
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5984
dc.descriptionAims It is well-known that unaccustomed exercise, especially eccentric exercise, is associated to delayed onset muscle soreness (DOMS). Whether DOMS is associated with reactive oxygen species (ROS) and the transient receptor potential vanilloid 1 (TRPV1) is still an open question. Thus, the aim of this study was to investigate the association between TRPV1 and xanthine oxidase-related ROS production in muscle and DOMS after a bout of eccentric exercise. Main methods Male Wistar rats performed a downhill running exercise on a treadmill at a - 16° tilt and a constant speed for 90 min (5 min/bout separated by 2 min of rest). Mechanical allodynia and grip force tests were performed before and 1, 3, 6, 9, 12, 24, 48 and 72 h after the downhill running. Biochemical assays probing oxidative stress, purine degradation, xanthine oxidase activity, Ca2 + ATPase activity and TRPV1 protein content were performed in gastrocnemius muscle at 12, 24, and 48 h after the downhill running. Key findings Our statistical analysis showed an increase in mechanical allodynia and a loss of strength after the downhill running. Similarly, an increase in carbonyl, xanthine oxidase activity, uric acid levels and TRPV1 immunoreactivity were found 12 h post-exercise. On the other hand, Ca2 + ATPase activity decreased in all analyzed times. Significance Our results suggest that a possible relationship between xanthine oxidase-related ROS and TRPV1 may exist during the events preceding eccentric exercise-related DOMS. © 2016 Elsevier Inc. All rights reserved.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectDOMS
dc.subjectEccentric exercise
dc.subjectOxidative stress
dc.subjectTRPV1
dc.subjectXanthine oxidase
dc.subjectadenosine triphosphatase (calcium)
dc.subjectreactive oxygen metabolite
dc.subjecturic acid
dc.subjectvanilloid receptor 1
dc.subjectxanthine oxidase
dc.subjectadenosine triphosphatase (calcium)
dc.subjectantioxidant
dc.subjectreactive oxygen metabolite
dc.subjectTrpv1 protein, rat
dc.subjectvanilloid receptor
dc.subjectxanthine oxidase
dc.subjectadult
dc.subjectallodynia
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectdelayed onset muscle soreness
dc.subjectenzyme activity
dc.subjectenzyme degradation
dc.subjectexercise
dc.subjectgastrocnemius muscle
dc.subjectgrip strength
dc.subjecthigh performance liquid chromatography
dc.subjectmale
dc.subjectmotor performance
dc.subjectmuscle disease
dc.subjectnonhuman
dc.subjectprotein determination
dc.subjectprotein synthesis
dc.subjectrat
dc.subjectrunning
dc.subjectanimal
dc.subjectbiosynthesis
dc.subjectdrug effects
dc.subjectenzymology
dc.subjectexercise
dc.subjecthand strength
dc.subjecthyperalgesia
dc.subjectmetabolism
dc.subjectmyalgia
dc.subjectphysiology
dc.subjectprotein carbonylation
dc.subjectpsychology
dc.subjectskeletal muscle
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCalcium-Transporting ATPases
dc.subjectHand Strength
dc.subjectHyperalgesia
dc.subjectMale
dc.subjectMuscle, Skeletal
dc.subjectMyalgia
dc.subjectPhysical Exertion
dc.subjectProtein Carbonylation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReactive Oxygen Species
dc.subjectRunning
dc.subjectTRPV Cation Channels
dc.subjectUric Acid
dc.subjectXanthine Oxidase
dc.titleIncreased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats
dc.typeArticle


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