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Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats
dc.contributor.author | Retamoso L.T. | |
dc.contributor.author | Silveira M.E.P. | |
dc.contributor.author | Jr. | |
dc.contributor.author | Lima F.D. | |
dc.contributor.author | Busanello G.L. | |
dc.contributor.author | Bresciani G. | |
dc.contributor.author | Ribeiro L.R. | |
dc.contributor.author | Chagas P.M. | |
dc.contributor.author | Nogueira C.W. | |
dc.contributor.author | Braga A.C.M. | |
dc.contributor.author | Furian A.F. | |
dc.contributor.author | Oliveira M.S. | |
dc.contributor.author | Fighera M.R. | |
dc.contributor.author | Royes L.F.F. | |
dc.date.accessioned | 2020-09-02T22:26:55Z | |
dc.date.available | 2020-09-02T22:26:55Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1016/j.lfs.2016.03.029 | |
dc.identifier.citation | 152, , 52-59 | |
dc.identifier.issn | 00243205 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/5984 | |
dc.description | Aims It is well-known that unaccustomed exercise, especially eccentric exercise, is associated to delayed onset muscle soreness (DOMS). Whether DOMS is associated with reactive oxygen species (ROS) and the transient receptor potential vanilloid 1 (TRPV1) is still an open question. Thus, the aim of this study was to investigate the association between TRPV1 and xanthine oxidase-related ROS production in muscle and DOMS after a bout of eccentric exercise. Main methods Male Wistar rats performed a downhill running exercise on a treadmill at a - 16° tilt and a constant speed for 90 min (5 min/bout separated by 2 min of rest). Mechanical allodynia and grip force tests were performed before and 1, 3, 6, 9, 12, 24, 48 and 72 h after the downhill running. Biochemical assays probing oxidative stress, purine degradation, xanthine oxidase activity, Ca2 + ATPase activity and TRPV1 protein content were performed in gastrocnemius muscle at 12, 24, and 48 h after the downhill running. Key findings Our statistical analysis showed an increase in mechanical allodynia and a loss of strength after the downhill running. Similarly, an increase in carbonyl, xanthine oxidase activity, uric acid levels and TRPV1 immunoreactivity were found 12 h post-exercise. On the other hand, Ca2 + ATPase activity decreased in all analyzed times. Significance Our results suggest that a possible relationship between xanthine oxidase-related ROS and TRPV1 may exist during the events preceding eccentric exercise-related DOMS. © 2016 Elsevier Inc. All rights reserved. | |
dc.language.iso | en | |
dc.publisher | Elsevier Inc. | |
dc.subject | DOMS | |
dc.subject | Eccentric exercise | |
dc.subject | Oxidative stress | |
dc.subject | TRPV1 | |
dc.subject | Xanthine oxidase | |
dc.subject | adenosine triphosphatase (calcium) | |
dc.subject | reactive oxygen metabolite | |
dc.subject | uric acid | |
dc.subject | vanilloid receptor 1 | |
dc.subject | xanthine oxidase | |
dc.subject | adenosine triphosphatase (calcium) | |
dc.subject | antioxidant | |
dc.subject | reactive oxygen metabolite | |
dc.subject | Trpv1 protein, rat | |
dc.subject | vanilloid receptor | |
dc.subject | xanthine oxidase | |
dc.subject | adult | |
dc.subject | allodynia | |
dc.subject | animal experiment | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | delayed onset muscle soreness | |
dc.subject | enzyme activity | |
dc.subject | enzyme degradation | |
dc.subject | exercise | |
dc.subject | gastrocnemius muscle | |
dc.subject | grip strength | |
dc.subject | high performance liquid chromatography | |
dc.subject | male | |
dc.subject | motor performance | |
dc.subject | muscle disease | |
dc.subject | nonhuman | |
dc.subject | protein determination | |
dc.subject | protein synthesis | |
dc.subject | rat | |
dc.subject | running | |
dc.subject | animal | |
dc.subject | biosynthesis | |
dc.subject | drug effects | |
dc.subject | enzymology | |
dc.subject | exercise | |
dc.subject | hand strength | |
dc.subject | hyperalgesia | |
dc.subject | metabolism | |
dc.subject | myalgia | |
dc.subject | physiology | |
dc.subject | protein carbonylation | |
dc.subject | psychology | |
dc.subject | skeletal muscle | |
dc.subject | Wistar rat | |
dc.subject | Animals | |
dc.subject | Antioxidants | |
dc.subject | Calcium-Transporting ATPases | |
dc.subject | Hand Strength | |
dc.subject | Hyperalgesia | |
dc.subject | Male | |
dc.subject | Muscle, Skeletal | |
dc.subject | Myalgia | |
dc.subject | Physical Exertion | |
dc.subject | Protein Carbonylation | |
dc.subject | Rats | |
dc.subject | Rats, Wistar | |
dc.subject | Reactive Oxygen Species | |
dc.subject | Running | |
dc.subject | TRPV Cation Channels | |
dc.subject | Uric Acid | |
dc.subject | Xanthine Oxidase | |
dc.title | Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats | |
dc.type | Article |