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Diseases associated with leaky hemichannels

dc.contributor.authorRetamal M.A.
dc.contributor.authorReyes E.P.
dc.contributor.authorGarcía I.E.
dc.contributor.authorPinto B.
dc.contributor.authorMartínez A.D.
dc.contributor.authorGonzález C.
dc.date.accessioned2020-09-02T22:26:55Z
dc.date.available2020-09-02T22:26:55Z
dc.date.issued2015
dc.identifier10.3389/fncel.2015.00267
dc.identifier.citation9, JULY, -
dc.identifier.issn16625102
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5981
dc.descriptionHemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells. Under physiological conditions, HCs are mostly closed, but they can open under certain stimuli allowing the release of autocrine and paracrine molecules. Moreover, some pathological conditions, like ischemia or other inflammation conditions, significantly increase HCs activity. In addition, some mutations in Cx genes associated with human diseases, such as deafness or cataracts, lead to the formation of more active HCs or “leaky HCs.” In this article we will revise cellular and molecular mechanisms underlying the appearance of leaky HCs, and the consequences of their expression in different cellular systems and animal models, in seeking a common pattern or pathological mechanism of disease. © 2015 Retamal, Reyes, García, Pinto, Martínez and González.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectCell death
dc.subjectConnexins
dc.subjectDisease
dc.subjectGap junction channels
dc.subjectLeaky hemichannels
dc.subjectMutations
dc.subjectgap junction protein
dc.subjectautocrine effect
dc.subjectbiotinylation
dc.subjectcataract
dc.subjectcell communication
dc.subjectchromosome rearrangement
dc.subjectdegenerative disease
dc.subjectdisease association
dc.subjectelectrophysiology
dc.subjectgap junction
dc.subjectgene mutation
dc.subjecthearing impairment
dc.subjectheart disease
dc.subjecthuman
dc.subjectimmunolocalization
dc.subjectinflammation
dc.subjectischemia
dc.subjectmembrane permeability
dc.subjectnonhuman
dc.subjectoculodentodigital syndrome
dc.subjectparacrine signaling
dc.subjectprotein expression
dc.subjectReview
dc.subjectskin disease
dc.subjectsynaptic transmission
dc.titleDiseases associated with leaky hemichannels
dc.typeReview


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