Mostrar el registro sencillo del ítem

Extracellular cysteine in connexins: Role as redox sensors

dc.contributor.authorRetamal M.A.
dc.contributor.authorGarcía I.E.
dc.contributor.authorPinto B.I.
dc.contributor.authorPupo A.
dc.contributor.authorBáez D.
dc.contributor.authorStehberg J.
dc.contributor.authorDel Rio R.
dc.contributor.authorGonzález C.
dc.date.accessioned2020-09-02T22:26:55Z
dc.date.available2020-09-02T22:26:55Z
dc.date.issued2016
dc.identifier10.3389/fphys.2016.00001
dc.identifier.citation7, JAN, -
dc.identifier.issn1664042X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5978
dc.descriptionConnexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa. Similarly, the opening of gap junction channels permits the diffusional exchange of ions and molecules between the cytoplasm and contacting cells. The controlled opening of hemichannels has been associated with several physiological cellular processes; thereby unregulated hemichannel activity may induce loss of cellular homeostasis and cell death. Hemichannel activity can be regulated through several mechanisms, such as phosphorylation, divalent cations and changes in membrane potential. Additionally, it was recently postulated that redox molecules could modify hemichannels properties in vitro. However, the molecular mechanism by which redox molecules interact with hemichannels is poorly understood. In this work, we discuss the current knowledge on connexin redox regulation and we propose the hypothesis that extracellular cysteines could be important for sensing changes in redox potential. Future studies on this topic will offer new insight into hemichannel function, thereby expanding the understanding of the contribution of hemichannels to disease progression. © 2016 Retamal, García, Pinto, Pupo, Báez, Stehberg, Del Rio and González.
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectConnexins
dc.subjectGap junction channels
dc.subjectGaseous transmitters
dc.subjectHemichannels
dc.subjectPost-translational modification
dc.subjectRedox potential
dc.subjectcysteine
dc.subjectgap junction protein
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell survival
dc.subjectchannel gating
dc.subjecthuman
dc.subjectmolecular dynamics
dc.subjectoxidation reduction potential
dc.subjectoxidation reduction state
dc.subjectprotein determination
dc.subjectprotein function
dc.subjectprotein localization
dc.subjectprotein phosphorylation
dc.subjectretina
dc.titleExtracellular cysteine in connexins: Role as redox sensors
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84962689830.pdf
Tamaño:
2.783Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem